Malaria Vaccines

Recent Advances and New Horizons

Simon J. Draper, Brandon Wilder, C. Richter King, Carolyn M. Nielsen, Julian C. Rayner, Matthew K. Higgins, Carole A. Long, Robert A. Seder

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success. Here we review the latest vaccine approaches that seek to prevent malaria infection, disease, and transmission and highlight some of the major underlying immunological and molecular mechanisms of protection. The synthesis of rational antigen selection, immunogen design, and immunization strategies to induce quantitatively and qualitatively improved immune effector mechanisms offers promise for achieving sustained high-level protection. Development of highly effective vaccines against human malaria remains a public health priority. In this Review, Draper et al. describe the latest vaccine approaches to prevent malaria alongside immunological and molecular mechanisms of protection. Rational antigen selection, immunogen design, and novel immunization strategies offer promise for achieving high-level protection.

Original languageEnglish (US)
Pages (from-to)43-56
Number of pages14
JournalCell Host and Microbe
Volume24
Issue number1
DOIs
StatePublished - Jul 11 2018
Externally publishedYes

Fingerprint

Malaria Vaccines
Vaccines
Malaria
Immunization
Antigens
Health Priorities
Infectious Disease Transmission
Falciparum Malaria
Licensure
Parasites
Public Health
Research

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Cite this

Draper, S. J., Wilder, B., King, C. R., Nielsen, C. M., Rayner, J. C., Higgins, M. K., ... Seder, R. A. (2018). Malaria Vaccines: Recent Advances and New Horizons. Cell Host and Microbe, 24(1), 43-56. https://doi.org/10.1016/j.chom.2018.06.008

Malaria Vaccines : Recent Advances and New Horizons. / Draper, Simon J.; Wilder, Brandon; King, C. Richter; Nielsen, Carolyn M.; Rayner, Julian C.; Higgins, Matthew K.; Long, Carole A.; Seder, Robert A.

In: Cell Host and Microbe, Vol. 24, No. 1, 11.07.2018, p. 43-56.

Research output: Contribution to journalReview article

Draper, SJ, Wilder, B, King, CR, Nielsen, CM, Rayner, JC, Higgins, MK, Long, CA & Seder, RA 2018, 'Malaria Vaccines: Recent Advances and New Horizons', Cell Host and Microbe, vol. 24, no. 1, pp. 43-56. https://doi.org/10.1016/j.chom.2018.06.008
Draper SJ, Wilder B, King CR, Nielsen CM, Rayner JC, Higgins MK et al. Malaria Vaccines: Recent Advances and New Horizons. Cell Host and Microbe. 2018 Jul 11;24(1):43-56. https://doi.org/10.1016/j.chom.2018.06.008
Draper, Simon J. ; Wilder, Brandon ; King, C. Richter ; Nielsen, Carolyn M. ; Rayner, Julian C. ; Higgins, Matthew K. ; Long, Carole A. ; Seder, Robert A. / Malaria Vaccines : Recent Advances and New Horizons. In: Cell Host and Microbe. 2018 ; Vol. 24, No. 1. pp. 43-56.
@article{dd3660923cdf4fcbafa91cb1fb0dda87,
title = "Malaria Vaccines: Recent Advances and New Horizons",
abstract = "The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success. Here we review the latest vaccine approaches that seek to prevent malaria infection, disease, and transmission and highlight some of the major underlying immunological and molecular mechanisms of protection. The synthesis of rational antigen selection, immunogen design, and immunization strategies to induce quantitatively and qualitatively improved immune effector mechanisms offers promise for achieving sustained high-level protection. Development of highly effective vaccines against human malaria remains a public health priority. In this Review, Draper et al. describe the latest vaccine approaches to prevent malaria alongside immunological and molecular mechanisms of protection. Rational antigen selection, immunogen design, and novel immunization strategies offer promise for achieving high-level protection.",
author = "Draper, {Simon J.} and Brandon Wilder and King, {C. Richter} and Nielsen, {Carolyn M.} and Rayner, {Julian C.} and Higgins, {Matthew K.} and Long, {Carole A.} and Seder, {Robert A.}",
year = "2018",
month = "7",
day = "11",
doi = "10.1016/j.chom.2018.06.008",
language = "English (US)",
volume = "24",
pages = "43--56",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Malaria Vaccines

T2 - Recent Advances and New Horizons

AU - Draper, Simon J.

AU - Wilder, Brandon

AU - King, C. Richter

AU - Nielsen, Carolyn M.

AU - Rayner, Julian C.

AU - Higgins, Matthew K.

AU - Long, Carole A.

AU - Seder, Robert A.

PY - 2018/7/11

Y1 - 2018/7/11

N2 - The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success. Here we review the latest vaccine approaches that seek to prevent malaria infection, disease, and transmission and highlight some of the major underlying immunological and molecular mechanisms of protection. The synthesis of rational antigen selection, immunogen design, and immunization strategies to induce quantitatively and qualitatively improved immune effector mechanisms offers promise for achieving sustained high-level protection. Development of highly effective vaccines against human malaria remains a public health priority. In this Review, Draper et al. describe the latest vaccine approaches to prevent malaria alongside immunological and molecular mechanisms of protection. Rational antigen selection, immunogen design, and novel immunization strategies offer promise for achieving high-level protection.

AB - The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success. Here we review the latest vaccine approaches that seek to prevent malaria infection, disease, and transmission and highlight some of the major underlying immunological and molecular mechanisms of protection. The synthesis of rational antigen selection, immunogen design, and immunization strategies to induce quantitatively and qualitatively improved immune effector mechanisms offers promise for achieving sustained high-level protection. Development of highly effective vaccines against human malaria remains a public health priority. In this Review, Draper et al. describe the latest vaccine approaches to prevent malaria alongside immunological and molecular mechanisms of protection. Rational antigen selection, immunogen design, and novel immunization strategies offer promise for achieving high-level protection.

UR - http://www.scopus.com/inward/record.url?scp=85049324228&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049324228&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2018.06.008

DO - 10.1016/j.chom.2018.06.008

M3 - Review article

VL - 24

SP - 43

EP - 56

JO - Cell Host and Microbe

JF - Cell Host and Microbe

SN - 1931-3128

IS - 1

ER -