Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders

Amy Paller, Jennifer C. Jaworski, Eric Simpson, Mark Boguniewicz, John J. Russell, Julie K. Block, Susan Tofte, Jeffrey D. Dunn, Steven R. Feldman, Adele R. Clark, Gene Schwartz, Lawrence F. Eichenfield

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated with several mental health comorbidities particularly attention-deficit hyperactivity disorder, anxiety, and depression. Data are largely inconsistent for specific cancers, but atopic dermatitis appears to protect against malignancy overall; severe long-term atopic dermatitis is associated with adult lymphomas. Atopic dermatitis may also be associated with obesity, cardiovascular disease, and autoimmune disease, particularly alopecia areata and gastrointestinal immune-mediated disorders. Although the causative mechanisms underlying these associations are poorly understood, treating physicians should be aware of associations in seeking to alleviate the burden for patients with atopic dermatitis.

Original languageEnglish (US)
Pages (from-to)821-838
Number of pages18
JournalAmerican Journal of Clinical Dermatology
Volume19
Issue number6
DOIs
StatePublished - Dec 1 2018

Fingerprint

Atopic Dermatitis
Comorbidity
Skin
Alopecia Areata
Immune System Diseases
Virus Diseases
Attention Deficit Disorder with Hyperactivity
Bacterial Infections
Autoimmune Diseases
Lymphoma
Neoplasms
Mental Health
Cardiovascular Diseases
Anxiety
Obesity
Depression
Physicians
Costs and Cost Analysis
Infection

ASJC Scopus subject areas

  • Dermatology

Cite this

Paller, A., Jaworski, J. C., Simpson, E., Boguniewicz, M., Russell, J. J., Block, J. K., ... Eichenfield, L. F. (2018). Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders. American Journal of Clinical Dermatology, 19(6), 821-838. https://doi.org/10.1007/s40257-018-0383-4

Major Comorbidities of Atopic Dermatitis : Beyond Allergic Disorders. / Paller, Amy; Jaworski, Jennifer C.; Simpson, Eric; Boguniewicz, Mark; Russell, John J.; Block, Julie K.; Tofte, Susan; Dunn, Jeffrey D.; Feldman, Steven R.; Clark, Adele R.; Schwartz, Gene; Eichenfield, Lawrence F.

In: American Journal of Clinical Dermatology, Vol. 19, No. 6, 01.12.2018, p. 821-838.

Research output: Contribution to journalReview article

Paller, A, Jaworski, JC, Simpson, E, Boguniewicz, M, Russell, JJ, Block, JK, Tofte, S, Dunn, JD, Feldman, SR, Clark, AR, Schwartz, G & Eichenfield, LF 2018, 'Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders', American Journal of Clinical Dermatology, vol. 19, no. 6, pp. 821-838. https://doi.org/10.1007/s40257-018-0383-4
Paller, Amy ; Jaworski, Jennifer C. ; Simpson, Eric ; Boguniewicz, Mark ; Russell, John J. ; Block, Julie K. ; Tofte, Susan ; Dunn, Jeffrey D. ; Feldman, Steven R. ; Clark, Adele R. ; Schwartz, Gene ; Eichenfield, Lawrence F. / Major Comorbidities of Atopic Dermatitis : Beyond Allergic Disorders. In: American Journal of Clinical Dermatology. 2018 ; Vol. 19, No. 6. pp. 821-838.
@article{3e8ca12690e24ee8918409500659b151,
title = "Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders",
abstract = "The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated with several mental health comorbidities particularly attention-deficit hyperactivity disorder, anxiety, and depression. Data are largely inconsistent for specific cancers, but atopic dermatitis appears to protect against malignancy overall; severe long-term atopic dermatitis is associated with adult lymphomas. Atopic dermatitis may also be associated with obesity, cardiovascular disease, and autoimmune disease, particularly alopecia areata and gastrointestinal immune-mediated disorders. Although the causative mechanisms underlying these associations are poorly understood, treating physicians should be aware of associations in seeking to alleviate the burden for patients with atopic dermatitis.",
author = "Amy Paller and Jaworski, {Jennifer C.} and Eric Simpson and Mark Boguniewicz and Russell, {John J.} and Block, {Julie K.} and Susan Tofte and Dunn, {Jeffrey D.} and Feldman, {Steven R.} and Clark, {Adele R.} and Gene Schwartz and Eichenfield, {Lawrence F.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1007/s40257-018-0383-4",
language = "English (US)",
volume = "19",
pages = "821--838",
journal = "American Journal of Clinical Dermatology",
issn = "1175-0561",
publisher = "Adis International Ltd",
number = "6",

}

TY - JOUR

T1 - Major Comorbidities of Atopic Dermatitis

T2 - Beyond Allergic Disorders

AU - Paller, Amy

AU - Jaworski, Jennifer C.

AU - Simpson, Eric

AU - Boguniewicz, Mark

AU - Russell, John J.

AU - Block, Julie K.

AU - Tofte, Susan

AU - Dunn, Jeffrey D.

AU - Feldman, Steven R.

AU - Clark, Adele R.

AU - Schwartz, Gene

AU - Eichenfield, Lawrence F.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated with several mental health comorbidities particularly attention-deficit hyperactivity disorder, anxiety, and depression. Data are largely inconsistent for specific cancers, but atopic dermatitis appears to protect against malignancy overall; severe long-term atopic dermatitis is associated with adult lymphomas. Atopic dermatitis may also be associated with obesity, cardiovascular disease, and autoimmune disease, particularly alopecia areata and gastrointestinal immune-mediated disorders. Although the causative mechanisms underlying these associations are poorly understood, treating physicians should be aware of associations in seeking to alleviate the burden for patients with atopic dermatitis.

AB - The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated with several mental health comorbidities particularly attention-deficit hyperactivity disorder, anxiety, and depression. Data are largely inconsistent for specific cancers, but atopic dermatitis appears to protect against malignancy overall; severe long-term atopic dermatitis is associated with adult lymphomas. Atopic dermatitis may also be associated with obesity, cardiovascular disease, and autoimmune disease, particularly alopecia areata and gastrointestinal immune-mediated disorders. Although the causative mechanisms underlying these associations are poorly understood, treating physicians should be aware of associations in seeking to alleviate the burden for patients with atopic dermatitis.

UR - http://www.scopus.com/inward/record.url?scp=85057296953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057296953&partnerID=8YFLogxK

U2 - 10.1007/s40257-018-0383-4

DO - 10.1007/s40257-018-0383-4

M3 - Review article

C2 - 30168085

AN - SCOPUS:85057296953

VL - 19

SP - 821

EP - 838

JO - American Journal of Clinical Dermatology

JF - American Journal of Clinical Dermatology

SN - 1175-0561

IS - 6

ER -