Abstract
The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated with several mental health comorbidities particularly attention-deficit hyperactivity disorder, anxiety, and depression. Data are largely inconsistent for specific cancers, but atopic dermatitis appears to protect against malignancy overall; severe long-term atopic dermatitis is associated with adult lymphomas. Atopic dermatitis may also be associated with obesity, cardiovascular disease, and autoimmune disease, particularly alopecia areata and gastrointestinal immune-mediated disorders. Although the causative mechanisms underlying these associations are poorly understood, treating physicians should be aware of associations in seeking to alleviate the burden for patients with atopic dermatitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 821-838 |
| Number of pages | 18 |
| Journal | American Journal of Clinical Dermatology |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2018 |
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ASJC Scopus subject areas
- Dermatology
Cite this
Major Comorbidities of Atopic Dermatitis : Beyond Allergic Disorders. / Paller, Amy; Jaworski, Jennifer C.; Simpson, Eric; Boguniewicz, Mark; Russell, John J.; Block, Julie K.; Tofte, Susan; Dunn, Jeffrey D.; Feldman, Steven R.; Clark, Adele R.; Schwartz, Gene; Eichenfield, Lawrence F.
In: American Journal of Clinical Dermatology, Vol. 19, No. 6, 01.12.2018, p. 821-838.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Major Comorbidities of Atopic Dermatitis
T2 - Beyond Allergic Disorders
AU - Paller, Amy
AU - Jaworski, Jennifer C.
AU - Simpson, Eric
AU - Boguniewicz, Mark
AU - Russell, John J.
AU - Block, Julie K.
AU - Tofte, Susan
AU - Dunn, Jeffrey D.
AU - Feldman, Steven R.
AU - Clark, Adele R.
AU - Schwartz, Gene
AU - Eichenfield, Lawrence F.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated with several mental health comorbidities particularly attention-deficit hyperactivity disorder, anxiety, and depression. Data are largely inconsistent for specific cancers, but atopic dermatitis appears to protect against malignancy overall; severe long-term atopic dermatitis is associated with adult lymphomas. Atopic dermatitis may also be associated with obesity, cardiovascular disease, and autoimmune disease, particularly alopecia areata and gastrointestinal immune-mediated disorders. Although the causative mechanisms underlying these associations are poorly understood, treating physicians should be aware of associations in seeking to alleviate the burden for patients with atopic dermatitis.
AB - The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated with several mental health comorbidities particularly attention-deficit hyperactivity disorder, anxiety, and depression. Data are largely inconsistent for specific cancers, but atopic dermatitis appears to protect against malignancy overall; severe long-term atopic dermatitis is associated with adult lymphomas. Atopic dermatitis may also be associated with obesity, cardiovascular disease, and autoimmune disease, particularly alopecia areata and gastrointestinal immune-mediated disorders. Although the causative mechanisms underlying these associations are poorly understood, treating physicians should be aware of associations in seeking to alleviate the burden for patients with atopic dermatitis.
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UR - http://www.scopus.com/inward/citedby.url?scp=85057296953&partnerID=8YFLogxK
U2 - 10.1007/s40257-018-0383-4
DO - 10.1007/s40257-018-0383-4
M3 - Review article
C2 - 30168085
AN - SCOPUS:85057296953
VL - 19
SP - 821
EP - 838
JO - American Journal of Clinical Dermatology
JF - American Journal of Clinical Dermatology
SN - 1175-0561
IS - 6
ER -