MAIT cells and microbial immunity

Erin W. Meermeier, Melanie Harriff, Elham Karamooz, David Lewinsohn

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mucosal-associated invariant T (MAIT) cells, the most abundant T-cell subset in humans, are increasingly being recognized for their importance in microbial immunity. MAIT cells accumulate in almost every mucosal tissue examined, including the lung, liver and intestinal tract, where they can be activated through T-cell receptor (TCR) triggering as well as cytokine stimulation in response to a host of microbial products. In this review, we specifically discuss MAIT cell responses to bacterial and fungal infections, with a focus on responses that are both MR1-dependent and -independent, the evidence for diversity in MAIT TCR usage in response to discrete microbial products, protective immunity induced by MAIT cells, and MAIT cell antimicrobial functions in the context of these infections.

Original languageEnglish (US)
JournalImmunology and Cell Biology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Immunity
T-Cell Antigen Receptor
Mycoses
T-Lymphocyte Subsets
Bacterial Infections
Mucous Membrane
Mucosal-Associated Invariant T Cells
Cytokines
Lung
Liver
Infection

Keywords

  • Antimicrobial responses
  • Infection
  • MAIT cells
  • MR1
  • Mucosal immunology
  • Unconventional T cells

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

MAIT cells and microbial immunity. / Meermeier, Erin W.; Harriff, Melanie; Karamooz, Elham; Lewinsohn, David.

In: Immunology and Cell Biology, 01.01.2018.

Research output: Contribution to journalArticle

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