Magnetic resonance spectroscopic measurement of cellular thiol reduction-oxidation state

J. C. Livesey, R. N. Golden, E. G. Shankland, Z. Grunbaum, M. Wyman, K. A. Krohn

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Chromatographic and magnetic resonance spectroscopic measurements of thiol reduction-oxidation state in chemically constructed samples show close analytical agreement. This result, coupled with the synthesis of new probe molecules allowing greater sensitivity and lower toxicity, supports the development of an NMR method for non-invasive thiol redox measurement, an important variable in the response of tumors to radiation and chemotherapy.

Original languageEnglish (US)
Pages (from-to)755-757
Number of pages3
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume22
Issue number4
DOIs
StatePublished - 1992

Keywords

  • Nuclear magnetic resonance spectroscopy
  • Reduction-oxidation state
  • Thiols

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'Magnetic resonance spectroscopic measurement of cellular thiol reduction-oxidation state'. Together they form a unique fingerprint.

  • Cite this