Magnetic resonance spectroscopic measurement of cellular thiol reduction-oxidation state

J. C. Livesey, R. N. Golden, E. G. Shankland, Z. Grunbaum, M. Wyman, Kenneth Krohn

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chromatographic and magnetic resonance spectroscopic measurements of thiol reduction-oxidation state in chemically constructed samples show close analytical agreement. This result, coupled with the synthesis of new probe molecules allowing greater sensitivity and lower toxicity, supports the development of an NMR method for non-invasive thiol redox measurement, an important variable in the response of tumors to radiation and chemotherapy.

Original languageEnglish (US)
Pages (from-to)755-757
Number of pages3
JournalInternational journal of radiation oncology, biology, physics
Volume22
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Sulfhydryl Compounds
thiols
magnetic resonance
Magnetic Resonance Spectroscopy
oxidation
chemotherapy
toxicity
Oxidation-Reduction
tumors
Radiation
Drug Therapy
nuclear magnetic resonance
probes
sensitivity
radiation
synthesis
molecules
Neoplasms

Keywords

  • Nuclear magnetic resonance spectroscopy
  • Reduction-oxidation state
  • Thiols

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Magnetic resonance spectroscopic measurement of cellular thiol reduction-oxidation state. / Livesey, J. C.; Golden, R. N.; Shankland, E. G.; Grunbaum, Z.; Wyman, M.; Krohn, Kenneth.

In: International journal of radiation oncology, biology, physics, Vol. 22, No. 4, 1992, p. 755-757.

Research output: Contribution to journalArticle

Livesey, J. C. ; Golden, R. N. ; Shankland, E. G. ; Grunbaum, Z. ; Wyman, M. ; Krohn, Kenneth. / Magnetic resonance spectroscopic measurement of cellular thiol reduction-oxidation state. In: International journal of radiation oncology, biology, physics. 1992 ; Vol. 22, No. 4. pp. 755-757.
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