Magnetic Resonance Mediated Radiofrequency Ablation

Yik Kiong Hue, Alexander Guimaraes, Ouri Cohen, Erez Nevo, Abraham Roth, Jerome L. Ackerman, Jerome L. Ackerman

Research output: Contribution to journalArticle

Abstract

Objective: To introduce magnetic resonance mediated radiofrequency ablation (MR-RFA), in which the MRI scanner uniquely serves both diagnostic and therapeutic roles. In MR-RFA scanner-induced RF heating is channeled to the ablation site via a Larmor frequency RF pickup device and needle system, and controlled via the pulse sequence. Methods: MR-RFA was evaluated with simulation of electric and magnetic fields to predict the increase in local specific-absorption-rate (SAR). Temperature-time profiles were measured for different configurations of the device in agar phantoms and ex vivo bovine liver in a 1.5 T scanner. Temperature rise in MR-RFA was imaged using the proton resonance frequency method validated with fiber-optic thermometry. MR-RFA was performed on the livers of two healthy live pigs. Results: Simulations indicated a near 10-fold increase in SAR at the RFA needle tip. Temperature-time profiles depended significantly on the physical parameters of the device although both configurations tested yielded temperature increases sufficient for ablation. Resected livers from live ablations exhibited clear thermal lesions. Conclusion: MR-RFA holds potential for integrating RF ablation tumor therapy with MRI scanning. Significance: MR-RFA may add value to MRI with the addition of a potentially disposable ablation device while retaining MRI’s ability to provide real time procedure guidance and measurement of tissue temperature, perfusion and coagulation.

Original languageEnglish (US)
JournalIEEE Transactions on Medical Imaging
DOIs
StateAccepted/In press - Sep 16 2017

Fingerprint

Magnetic resonance
Ablation
Magnetic Resonance Spectroscopy
Temperature
Equipment and Supplies
Magnetic resonance imaging
Needles
Liver
Thermometry
Magnetic Fields
Heating
Agar
Protons
Swine
Perfusion
Hot Temperature
Pickups
Coagulation
Fiber optics
Therapeutics

Keywords

  • Heating systems
  • interventional radiology
  • liver cancer
  • Magnetic resonance
  • Magnetic resonance imaging
  • MRI
  • Power transmission lines
  • proton resonance frequency (PRF) shift thermal imaging
  • Radio frequency
  • radiofrequency ablation (RFA)
  • Tumors
  • Wires

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering

Cite this

Hue, Y. K., Guimaraes, A., Cohen, O., Nevo, E., Roth, A., Ackerman, J. L., & Ackerman, J. L. (Accepted/In press). Magnetic Resonance Mediated Radiofrequency Ablation. IEEE Transactions on Medical Imaging. https://doi.org/10.1109/TMI.2017.2753739

Magnetic Resonance Mediated Radiofrequency Ablation. / Hue, Yik Kiong; Guimaraes, Alexander; Cohen, Ouri; Nevo, Erez; Roth, Abraham; Ackerman, Jerome L.; Ackerman, Jerome L.

In: IEEE Transactions on Medical Imaging, 16.09.2017.

Research output: Contribution to journalArticle

Hue, Yik Kiong ; Guimaraes, Alexander ; Cohen, Ouri ; Nevo, Erez ; Roth, Abraham ; Ackerman, Jerome L. ; Ackerman, Jerome L. / Magnetic Resonance Mediated Radiofrequency Ablation. In: IEEE Transactions on Medical Imaging. 2017.
@article{f6b88a243fba419dab7cd8fa530aca7e,
title = "Magnetic Resonance Mediated Radiofrequency Ablation",
abstract = "Objective: To introduce magnetic resonance mediated radiofrequency ablation (MR-RFA), in which the MRI scanner uniquely serves both diagnostic and therapeutic roles. In MR-RFA scanner-induced RF heating is channeled to the ablation site via a Larmor frequency RF pickup device and needle system, and controlled via the pulse sequence. Methods: MR-RFA was evaluated with simulation of electric and magnetic fields to predict the increase in local specific-absorption-rate (SAR). Temperature-time profiles were measured for different configurations of the device in agar phantoms and ex vivo bovine liver in a 1.5 T scanner. Temperature rise in MR-RFA was imaged using the proton resonance frequency method validated with fiber-optic thermometry. MR-RFA was performed on the livers of two healthy live pigs. Results: Simulations indicated a near 10-fold increase in SAR at the RFA needle tip. Temperature-time profiles depended significantly on the physical parameters of the device although both configurations tested yielded temperature increases sufficient for ablation. Resected livers from live ablations exhibited clear thermal lesions. Conclusion: MR-RFA holds potential for integrating RF ablation tumor therapy with MRI scanning. Significance: MR-RFA may add value to MRI with the addition of a potentially disposable ablation device while retaining MRI’s ability to provide real time procedure guidance and measurement of tissue temperature, perfusion and coagulation.",
keywords = "Heating systems, interventional radiology, liver cancer, Magnetic resonance, Magnetic resonance imaging, MRI, Power transmission lines, proton resonance frequency (PRF) shift thermal imaging, Radio frequency, radiofrequency ablation (RFA), Tumors, Wires",
author = "Hue, {Yik Kiong} and Alexander Guimaraes and Ouri Cohen and Erez Nevo and Abraham Roth and Ackerman, {Jerome L.} and Ackerman, {Jerome L.}",
year = "2017",
month = "9",
day = "16",
doi = "10.1109/TMI.2017.2753739",
language = "English (US)",
journal = "IEEE Transactions on Medical Imaging",
issn = "0278-0062",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

TY - JOUR

T1 - Magnetic Resonance Mediated Radiofrequency Ablation

AU - Hue, Yik Kiong

AU - Guimaraes, Alexander

AU - Cohen, Ouri

AU - Nevo, Erez

AU - Roth, Abraham

AU - Ackerman, Jerome L.

AU - Ackerman, Jerome L.

PY - 2017/9/16

Y1 - 2017/9/16

N2 - Objective: To introduce magnetic resonance mediated radiofrequency ablation (MR-RFA), in which the MRI scanner uniquely serves both diagnostic and therapeutic roles. In MR-RFA scanner-induced RF heating is channeled to the ablation site via a Larmor frequency RF pickup device and needle system, and controlled via the pulse sequence. Methods: MR-RFA was evaluated with simulation of electric and magnetic fields to predict the increase in local specific-absorption-rate (SAR). Temperature-time profiles were measured for different configurations of the device in agar phantoms and ex vivo bovine liver in a 1.5 T scanner. Temperature rise in MR-RFA was imaged using the proton resonance frequency method validated with fiber-optic thermometry. MR-RFA was performed on the livers of two healthy live pigs. Results: Simulations indicated a near 10-fold increase in SAR at the RFA needle tip. Temperature-time profiles depended significantly on the physical parameters of the device although both configurations tested yielded temperature increases sufficient for ablation. Resected livers from live ablations exhibited clear thermal lesions. Conclusion: MR-RFA holds potential for integrating RF ablation tumor therapy with MRI scanning. Significance: MR-RFA may add value to MRI with the addition of a potentially disposable ablation device while retaining MRI’s ability to provide real time procedure guidance and measurement of tissue temperature, perfusion and coagulation.

AB - Objective: To introduce magnetic resonance mediated radiofrequency ablation (MR-RFA), in which the MRI scanner uniquely serves both diagnostic and therapeutic roles. In MR-RFA scanner-induced RF heating is channeled to the ablation site via a Larmor frequency RF pickup device and needle system, and controlled via the pulse sequence. Methods: MR-RFA was evaluated with simulation of electric and magnetic fields to predict the increase in local specific-absorption-rate (SAR). Temperature-time profiles were measured for different configurations of the device in agar phantoms and ex vivo bovine liver in a 1.5 T scanner. Temperature rise in MR-RFA was imaged using the proton resonance frequency method validated with fiber-optic thermometry. MR-RFA was performed on the livers of two healthy live pigs. Results: Simulations indicated a near 10-fold increase in SAR at the RFA needle tip. Temperature-time profiles depended significantly on the physical parameters of the device although both configurations tested yielded temperature increases sufficient for ablation. Resected livers from live ablations exhibited clear thermal lesions. Conclusion: MR-RFA holds potential for integrating RF ablation tumor therapy with MRI scanning. Significance: MR-RFA may add value to MRI with the addition of a potentially disposable ablation device while retaining MRI’s ability to provide real time procedure guidance and measurement of tissue temperature, perfusion and coagulation.

KW - Heating systems

KW - interventional radiology

KW - liver cancer

KW - Magnetic resonance

KW - Magnetic resonance imaging

KW - MRI

KW - Power transmission lines

KW - proton resonance frequency (PRF) shift thermal imaging

KW - Radio frequency

KW - radiofrequency ablation (RFA)

KW - Tumors

KW - Wires

UR - http://www.scopus.com/inward/record.url?scp=85030633475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030633475&partnerID=8YFLogxK

U2 - 10.1109/TMI.2017.2753739

DO - 10.1109/TMI.2017.2753739

M3 - Article

JO - IEEE Transactions on Medical Imaging

JF - IEEE Transactions on Medical Imaging

SN - 0278-0062

ER -