Magnetic Resonance Imaging (MRI) detection of the marine brain response to light

Temporal differentiation and negative functional MRI changes

Wei Huang, Ildikó Pályka, Haifang Li, Edward M. Eisenstein, Nora D. Volkow, Charles Jr Springer

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings, (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates, (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex, another area displays decreased signal intensity upon stimulation.

Original languageEnglish (US)
Pages (from-to)6037-6042
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number12
StatePublished - Jun 11 1996
Externally publishedYes

Fingerprint

Magnetic Resonance Imaging
Light
Brain
Image Enhancement
Photic Stimulation
Visual Pathways
Electrophysiology
Visual Cortex
Arousal
Primates
Anesthesia

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Magnetic Resonance Imaging (MRI) detection of the marine brain response to light : Temporal differentiation and negative functional MRI changes. / Huang, Wei; Pályka, Ildikó; Li, Haifang; Eisenstein, Edward M.; Volkow, Nora D.; Springer, Charles Jr.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 12, 11.06.1996, p. 6037-6042.

Research output: Contribution to journalArticle

@article{57fbb82d260948b392750033a3bc28bd,
title = "Magnetic Resonance Imaging (MRI) detection of the marine brain response to light: Temporal differentiation and negative functional MRI changes",
abstract = "Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30{\%}) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings, (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates, (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex, another area displays decreased signal intensity upon stimulation.",
author = "Wei Huang and Ildik{\'o} P{\'a}lyka and Haifang Li and Eisenstein, {Edward M.} and Volkow, {Nora D.} and Springer, {Charles Jr}",
year = "1996",
month = "6",
day = "11",
language = "English (US)",
volume = "93",
pages = "6037--6042",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "12",

}

TY - JOUR

T1 - Magnetic Resonance Imaging (MRI) detection of the marine brain response to light

T2 - Temporal differentiation and negative functional MRI changes

AU - Huang, Wei

AU - Pályka, Ildikó

AU - Li, Haifang

AU - Eisenstein, Edward M.

AU - Volkow, Nora D.

AU - Springer, Charles Jr

PY - 1996/6/11

Y1 - 1996/6/11

N2 - Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings, (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates, (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex, another area displays decreased signal intensity upon stimulation.

AB - Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings, (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates, (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex, another area displays decreased signal intensity upon stimulation.

UR - http://www.scopus.com/inward/record.url?scp=0029999243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029999243&partnerID=8YFLogxK

M3 - Article

VL - 93

SP - 6037

EP - 6042

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 12

ER -