Magnetic Resonance Imaging (MRI) detection of the marine brain response to light: Temporal differentiation and negative functional MRI changes

Wei Huang, Ildikó Pályka, Haifang Li, Edward M. Eisenstein, Nora D. Volkow, Charles S. Springer

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Abstract

Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings, (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates, (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex, another area displays decreased signal intensity upon stimulation.

Original languageEnglish (US)
Pages (from-to)6037-6042
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number12
DOIs
StatePublished - Jun 11 1996

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