TY - JOUR
T1 - Magnetic Resonance Imaging (MRI) detection of the marine brain response to light
T2 - Temporal differentiation and negative functional MRI changes
AU - Huang, Wei
AU - Pályka, Ildikó
AU - Li, Haifang
AU - Eisenstein, Edward M.
AU - Volkow, Nora D.
AU - Springer, Charles S.
PY - 1996/6/11
Y1 - 1996/6/11
N2 - Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings, (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates, (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex, another area displays decreased signal intensity upon stimulation.
AB - Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings, (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates, (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex, another area displays decreased signal intensity upon stimulation.
UR - http://www.scopus.com/inward/record.url?scp=0029999243&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029999243&partnerID=8YFLogxK
U2 - 10.1073/pnas.93.12.6037
DO - 10.1073/pnas.93.12.6037
M3 - Article
C2 - 8650215
AN - SCOPUS:0029999243
SN - 0027-8424
VL - 93
SP - 6037
EP - 6042
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 12
ER -