Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy

a multicenter cross sectional study

Sean C. Forbes, Rebecca J. Willcocks, William T. Triplett, William Rooney, Donovan J. Lott, Dah Jyuu Wang, Jim Pollaro, Claudia R. Senesac, Michael J. Daniels, Richard S. Finkel, Barry S. Russman, Barry J. Byrne, Erika Finanger, Gihan I. Tennekoon, Glenn A. Walter, H. Lee Sweeney, Krista Vandenborne

Research output: Contribution to journalArticle

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Abstract

DISCUSSION: Overall, MR measures of T2 and lipid fraction revealed differences between DMD and Controls. Furthermore, MRI-T2 was greater in the older age group compared to the young age group, which was associated with higher lipid fractions. Overall, MR measures of T2 and lipid fraction show excellent sensitivity to DMD disease pathologies and potential therapeutic interventions in DMD, even in the younger boys.

INTRODUCTION: Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that results in functional deficits. However, these functional declines are often not able to be quantified in clinical trials for DMD until after age 7. In this study, we hypothesized that (1)H2O T2 derived using (1)H-MRS and MRI-T2 will be sensitive to muscle involvement at a young age (5-7 years) consistent with increased inflammation and muscle damage in a large cohort of DMD subjects compared to controls.

METHODS: MR data were acquired from 123 boys with DMD (ages 5-14 years; mean 8.6 SD 2.2 years) and 31 healthy controls (age 9.7 SD 2.3 years) using 3-Tesla MRI instruments at three institutions (University of Florida, Oregon Health & Science University, and Children's Hospital of Philadelphia). T2-weighted multi-slice spin echo (SE) axial images and single voxel 1H-MRS were acquired from the lower leg and thigh to measure lipid fraction and (1)H2O T2.

RESULTS: MRI-T2, (1)H2O T2, and lipid fraction were greater (p

Original languageEnglish (US)
Pages (from-to)e106435
JournalPLoS One
Volume9
Issue number9
DOIs
StatePublished - 2014

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muscular dystrophy
Duchenne Muscular Dystrophy
magnetic resonance imaging
cross-sectional studies
Magnetic resonance imaging
Muscle
skeletal muscle
spectroscopy
Lower Extremity
Skeletal Muscle
Magnetic Resonance Spectroscopy
Cross-Sectional Studies
Magnetic Resonance Imaging
Spectroscopy
Lipids
lipids
Age Groups
Pathology
Muscles
muscles

ASJC Scopus subject areas

  • Medicine(all)

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Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy : a multicenter cross sectional study. / Forbes, Sean C.; Willcocks, Rebecca J.; Triplett, William T.; Rooney, William; Lott, Donovan J.; Wang, Dah Jyuu; Pollaro, Jim; Senesac, Claudia R.; Daniels, Michael J.; Finkel, Richard S.; Russman, Barry S.; Byrne, Barry J.; Finanger, Erika; Tennekoon, Gihan I.; Walter, Glenn A.; Sweeney, H. Lee; Vandenborne, Krista.

In: PLoS One, Vol. 9, No. 9, 2014, p. e106435.

Research output: Contribution to journalArticle

Forbes, SC, Willcocks, RJ, Triplett, WT, Rooney, W, Lott, DJ, Wang, DJ, Pollaro, J, Senesac, CR, Daniels, MJ, Finkel, RS, Russman, BS, Byrne, BJ, Finanger, E, Tennekoon, GI, Walter, GA, Sweeney, HL & Vandenborne, K 2014, 'Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study', PLoS One, vol. 9, no. 9, pp. e106435. https://doi.org/10.1371/journal.pone.0106435
Forbes, Sean C. ; Willcocks, Rebecca J. ; Triplett, William T. ; Rooney, William ; Lott, Donovan J. ; Wang, Dah Jyuu ; Pollaro, Jim ; Senesac, Claudia R. ; Daniels, Michael J. ; Finkel, Richard S. ; Russman, Barry S. ; Byrne, Barry J. ; Finanger, Erika ; Tennekoon, Gihan I. ; Walter, Glenn A. ; Sweeney, H. Lee ; Vandenborne, Krista. / Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy : a multicenter cross sectional study. In: PLoS One. 2014 ; Vol. 9, No. 9. pp. e106435.
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abstract = "DISCUSSION: Overall, MR measures of T2 and lipid fraction revealed differences between DMD and Controls. Furthermore, MRI-T2 was greater in the older age group compared to the young age group, which was associated with higher lipid fractions. Overall, MR measures of T2 and lipid fraction show excellent sensitivity to DMD disease pathologies and potential therapeutic interventions in DMD, even in the younger boys.INTRODUCTION: Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that results in functional deficits. However, these functional declines are often not able to be quantified in clinical trials for DMD until after age 7. In this study, we hypothesized that (1)H2O T2 derived using (1)H-MRS and MRI-T2 will be sensitive to muscle involvement at a young age (5-7 years) consistent with increased inflammation and muscle damage in a large cohort of DMD subjects compared to controls.METHODS: MR data were acquired from 123 boys with DMD (ages 5-14 years; mean 8.6 SD 2.2 years) and 31 healthy controls (age 9.7 SD 2.3 years) using 3-Tesla MRI instruments at three institutions (University of Florida, Oregon Health & Science University, and Children's Hospital of Philadelphia). T2-weighted multi-slice spin echo (SE) axial images and single voxel 1H-MRS were acquired from the lower leg and thigh to measure lipid fraction and (1)H2O T2.RESULTS: MRI-T2, (1)H2O T2, and lipid fraction were greater (p",
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T1 - Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy

T2 - a multicenter cross sectional study

AU - Forbes, Sean C.

AU - Willcocks, Rebecca J.

AU - Triplett, William T.

AU - Rooney, William

AU - Lott, Donovan J.

AU - Wang, Dah Jyuu

AU - Pollaro, Jim

AU - Senesac, Claudia R.

AU - Daniels, Michael J.

AU - Finkel, Richard S.

AU - Russman, Barry S.

AU - Byrne, Barry J.

AU - Finanger, Erika

AU - Tennekoon, Gihan I.

AU - Walter, Glenn A.

AU - Sweeney, H. Lee

AU - Vandenborne, Krista

PY - 2014

Y1 - 2014

N2 - DISCUSSION: Overall, MR measures of T2 and lipid fraction revealed differences between DMD and Controls. Furthermore, MRI-T2 was greater in the older age group compared to the young age group, which was associated with higher lipid fractions. Overall, MR measures of T2 and lipid fraction show excellent sensitivity to DMD disease pathologies and potential therapeutic interventions in DMD, even in the younger boys.INTRODUCTION: Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that results in functional deficits. However, these functional declines are often not able to be quantified in clinical trials for DMD until after age 7. In this study, we hypothesized that (1)H2O T2 derived using (1)H-MRS and MRI-T2 will be sensitive to muscle involvement at a young age (5-7 years) consistent with increased inflammation and muscle damage in a large cohort of DMD subjects compared to controls.METHODS: MR data were acquired from 123 boys with DMD (ages 5-14 years; mean 8.6 SD 2.2 years) and 31 healthy controls (age 9.7 SD 2.3 years) using 3-Tesla MRI instruments at three institutions (University of Florida, Oregon Health & Science University, and Children's Hospital of Philadelphia). T2-weighted multi-slice spin echo (SE) axial images and single voxel 1H-MRS were acquired from the lower leg and thigh to measure lipid fraction and (1)H2O T2.RESULTS: MRI-T2, (1)H2O T2, and lipid fraction were greater (p

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