Magnetic resonance diffusion tensor imaging (MRDTI) and tractography in children with septo-optic dysplasia

Michael B. Salmela, Keith A. Cauley, Joshua Nickerson, Chris J. Koski, Christopher G. Filippi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background Septo-optic dysplasia (SOD) refers to a heterogeneous group of midline brain developmental anomalies, with optic nerve hypoplasia (ONH) being one of the morphologic correlates of the condition. Traditionally, ONH has been diagnosed on fundoscopic exam. Conventional MRI is used in cases of suspected ONH to identify associated brain abnormalities and to compare findings to the fundoscopic exam. Advances in magnetic resonance diffusion tensor imaging (MRDTI) permit in vivo, noninvasive, quantitative characterization of the entire visual pathway at 3.0 T. Objective To investigate the feasibility of MRDTI at 3.0 T in children with SOD to evaluate the entire visual pathway. Materials and methods MRDTI at 3T was performed in two children with SOD and seven age-matched controls. Manual region-of-interest analysis was used to evaluate the tensor metrics of the optic nerves. Deterministic tractography was used to evaluate the tensor metrics of the optic radiations. Results The SOD patients demonstrated a significant decrease in anisotropy and increase in mean diffusivity of the optic nerves and radiations compared to the control subjects. Conclusion This study demonstrates the feasibility of MRDTI to evaluate the entire visual pathway in children, and it demonstrates pre- and post-chiasmatic diffusion tensor abnormalities in SOD patients.

Original languageEnglish (US)
Pages (from-to)708-713
Number of pages6
JournalPediatric Radiology
Volume40
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

Fingerprint

Septo-Optic Dysplasia
Diffusion Tensor Imaging
Optic Nerve
Magnetic Resonance Spectroscopy
Visual Pathways
Radiation
Anisotropy
Brain
Feasibility Studies

Keywords

  • Children
  • Diffusion tensor imaging
  • DTI
  • Septo-optic dysplasia
  • Tractography

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

Cite this

Magnetic resonance diffusion tensor imaging (MRDTI) and tractography in children with septo-optic dysplasia. / Salmela, Michael B.; Cauley, Keith A.; Nickerson, Joshua; Koski, Chris J.; Filippi, Christopher G.

In: Pediatric Radiology, Vol. 40, No. 5, 01.05.2010, p. 708-713.

Research output: Contribution to journalArticle

Salmela, Michael B. ; Cauley, Keith A. ; Nickerson, Joshua ; Koski, Chris J. ; Filippi, Christopher G. / Magnetic resonance diffusion tensor imaging (MRDTI) and tractography in children with septo-optic dysplasia. In: Pediatric Radiology. 2010 ; Vol. 40, No. 5. pp. 708-713.
@article{c9b43efdd4204c028cf66fdeba78b8c7,
title = "Magnetic resonance diffusion tensor imaging (MRDTI) and tractography in children with septo-optic dysplasia",
abstract = "Background Septo-optic dysplasia (SOD) refers to a heterogeneous group of midline brain developmental anomalies, with optic nerve hypoplasia (ONH) being one of the morphologic correlates of the condition. Traditionally, ONH has been diagnosed on fundoscopic exam. Conventional MRI is used in cases of suspected ONH to identify associated brain abnormalities and to compare findings to the fundoscopic exam. Advances in magnetic resonance diffusion tensor imaging (MRDTI) permit in vivo, noninvasive, quantitative characterization of the entire visual pathway at 3.0 T. Objective To investigate the feasibility of MRDTI at 3.0 T in children with SOD to evaluate the entire visual pathway. Materials and methods MRDTI at 3T was performed in two children with SOD and seven age-matched controls. Manual region-of-interest analysis was used to evaluate the tensor metrics of the optic nerves. Deterministic tractography was used to evaluate the tensor metrics of the optic radiations. Results The SOD patients demonstrated a significant decrease in anisotropy and increase in mean diffusivity of the optic nerves and radiations compared to the control subjects. Conclusion This study demonstrates the feasibility of MRDTI to evaluate the entire visual pathway in children, and it demonstrates pre- and post-chiasmatic diffusion tensor abnormalities in SOD patients.",
keywords = "Children, Diffusion tensor imaging, DTI, Septo-optic dysplasia, Tractography",
author = "Salmela, {Michael B.} and Cauley, {Keith A.} and Joshua Nickerson and Koski, {Chris J.} and Filippi, {Christopher G.}",
year = "2010",
month = "5",
day = "1",
doi = "10.1007/s00247-009-1478-0",
language = "English (US)",
volume = "40",
pages = "708--713",
journal = "Pediatric Radiology",
issn = "0301-0449",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Magnetic resonance diffusion tensor imaging (MRDTI) and tractography in children with septo-optic dysplasia

AU - Salmela, Michael B.

AU - Cauley, Keith A.

AU - Nickerson, Joshua

AU - Koski, Chris J.

AU - Filippi, Christopher G.

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Background Septo-optic dysplasia (SOD) refers to a heterogeneous group of midline brain developmental anomalies, with optic nerve hypoplasia (ONH) being one of the morphologic correlates of the condition. Traditionally, ONH has been diagnosed on fundoscopic exam. Conventional MRI is used in cases of suspected ONH to identify associated brain abnormalities and to compare findings to the fundoscopic exam. Advances in magnetic resonance diffusion tensor imaging (MRDTI) permit in vivo, noninvasive, quantitative characterization of the entire visual pathway at 3.0 T. Objective To investigate the feasibility of MRDTI at 3.0 T in children with SOD to evaluate the entire visual pathway. Materials and methods MRDTI at 3T was performed in two children with SOD and seven age-matched controls. Manual region-of-interest analysis was used to evaluate the tensor metrics of the optic nerves. Deterministic tractography was used to evaluate the tensor metrics of the optic radiations. Results The SOD patients demonstrated a significant decrease in anisotropy and increase in mean diffusivity of the optic nerves and radiations compared to the control subjects. Conclusion This study demonstrates the feasibility of MRDTI to evaluate the entire visual pathway in children, and it demonstrates pre- and post-chiasmatic diffusion tensor abnormalities in SOD patients.

AB - Background Septo-optic dysplasia (SOD) refers to a heterogeneous group of midline brain developmental anomalies, with optic nerve hypoplasia (ONH) being one of the morphologic correlates of the condition. Traditionally, ONH has been diagnosed on fundoscopic exam. Conventional MRI is used in cases of suspected ONH to identify associated brain abnormalities and to compare findings to the fundoscopic exam. Advances in magnetic resonance diffusion tensor imaging (MRDTI) permit in vivo, noninvasive, quantitative characterization of the entire visual pathway at 3.0 T. Objective To investigate the feasibility of MRDTI at 3.0 T in children with SOD to evaluate the entire visual pathway. Materials and methods MRDTI at 3T was performed in two children with SOD and seven age-matched controls. Manual region-of-interest analysis was used to evaluate the tensor metrics of the optic nerves. Deterministic tractography was used to evaluate the tensor metrics of the optic radiations. Results The SOD patients demonstrated a significant decrease in anisotropy and increase in mean diffusivity of the optic nerves and radiations compared to the control subjects. Conclusion This study demonstrates the feasibility of MRDTI to evaluate the entire visual pathway in children, and it demonstrates pre- and post-chiasmatic diffusion tensor abnormalities in SOD patients.

KW - Children

KW - Diffusion tensor imaging

KW - DTI

KW - Septo-optic dysplasia

KW - Tractography

UR - http://www.scopus.com/inward/record.url?scp=77951498919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951498919&partnerID=8YFLogxK

U2 - 10.1007/s00247-009-1478-0

DO - 10.1007/s00247-009-1478-0

M3 - Article

VL - 40

SP - 708

EP - 713

JO - Pediatric Radiology

JF - Pediatric Radiology

SN - 0301-0449

IS - 5

ER -