Magnetic resonance cholangiography of biliary strictures after liver transplantation: A prospective double-blind study

Mary T. Kitazono, Aliya Qayyum, Benjamin M. Yeh, Paul S. Chard, James W. Ostroff, Fergus Coakley

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Purpose: To compare magnetic resonance cholangiography (MRC) with endoscopic retrograde cholangiography (ERC) in quantitatively evaluating biliary strictures in liver transplant recipients. Materials and Methods: Eight liver transplant recipients with suspected biliary complications were referred for ERC and also underwent MRC within 24 hours using a combination of single-shot rapid acquisition with relaxation enhancement (SS-RARE) and three-dimensional (3D)-RARE sequences. The studies were independently interpreted by two blinded radiologists and a single blinded endoscopist who recorded the presence of a stricture and/or upstream dilatation, the ratio of recipient-to-donor duct diameters at the anastomosis, as well as the proximal duct diameter, length, and percent stenosis of any stricture detected. Results: Using ERC as the standard of reference, MRC had a sensitivity and negative predictive value of 100%, mean specificity of 83.3%. and mean positive predictive value of 92.9% in the detection of six strictures. Compared with ERC, MRC obtained accurate measurements of recipient-to-donor duct diameter ratios (r, 0.91; P <0.01), proximal duct diameters (r, 0.83. P <0.05), stricture lengths (r, 0.58; P = 0.06), and percent stenosis (r, 0.78; P = 0.06). Conclusion: MRC can provide equivalent imaging to ERC and can reliably identify and quantitatively evaluate biliary strictures in post-orthotopic liver transplantation (OLT) patients.

Original languageEnglish (US)
Pages (from-to)1168-1173
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume25
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

Cholangiography
Double-Blind Method
Liver Transplantation
Pathologic Constriction
Magnetic Resonance Spectroscopy
Tissue Donors
Liver
Dilatation

Keywords

  • Bile duct stricture
  • Endoscopic retrograde cholangiopancreatography
  • Liver transplantation
  • Magnetic resonance cholangiopancreatography
  • Three dimensional imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetic resonance cholangiography of biliary strictures after liver transplantation : A prospective double-blind study. / Kitazono, Mary T.; Qayyum, Aliya; Yeh, Benjamin M.; Chard, Paul S.; Ostroff, James W.; Coakley, Fergus.

In: Journal of Magnetic Resonance Imaging, Vol. 25, No. 6, 06.2007, p. 1168-1173.

Research output: Contribution to journalArticle

Kitazono, Mary T. ; Qayyum, Aliya ; Yeh, Benjamin M. ; Chard, Paul S. ; Ostroff, James W. ; Coakley, Fergus. / Magnetic resonance cholangiography of biliary strictures after liver transplantation : A prospective double-blind study. In: Journal of Magnetic Resonance Imaging. 2007 ; Vol. 25, No. 6. pp. 1168-1173.
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abstract = "Purpose: To compare magnetic resonance cholangiography (MRC) with endoscopic retrograde cholangiography (ERC) in quantitatively evaluating biliary strictures in liver transplant recipients. Materials and Methods: Eight liver transplant recipients with suspected biliary complications were referred for ERC and also underwent MRC within 24 hours using a combination of single-shot rapid acquisition with relaxation enhancement (SS-RARE) and three-dimensional (3D)-RARE sequences. The studies were independently interpreted by two blinded radiologists and a single blinded endoscopist who recorded the presence of a stricture and/or upstream dilatation, the ratio of recipient-to-donor duct diameters at the anastomosis, as well as the proximal duct diameter, length, and percent stenosis of any stricture detected. Results: Using ERC as the standard of reference, MRC had a sensitivity and negative predictive value of 100{\%}, mean specificity of 83.3{\%}. and mean positive predictive value of 92.9{\%} in the detection of six strictures. Compared with ERC, MRC obtained accurate measurements of recipient-to-donor duct diameter ratios (r, 0.91; P <0.01), proximal duct diameters (r, 0.83. P <0.05), stricture lengths (r, 0.58; P = 0.06), and percent stenosis (r, 0.78; P = 0.06). Conclusion: MRC can provide equivalent imaging to ERC and can reliably identify and quantitatively evaluate biliary strictures in post-orthotopic liver transplantation (OLT) patients.",
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AU - Yeh, Benjamin M.

AU - Chard, Paul S.

AU - Ostroff, James W.

AU - Coakley, Fergus

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N2 - Purpose: To compare magnetic resonance cholangiography (MRC) with endoscopic retrograde cholangiography (ERC) in quantitatively evaluating biliary strictures in liver transplant recipients. Materials and Methods: Eight liver transplant recipients with suspected biliary complications were referred for ERC and also underwent MRC within 24 hours using a combination of single-shot rapid acquisition with relaxation enhancement (SS-RARE) and three-dimensional (3D)-RARE sequences. The studies were independently interpreted by two blinded radiologists and a single blinded endoscopist who recorded the presence of a stricture and/or upstream dilatation, the ratio of recipient-to-donor duct diameters at the anastomosis, as well as the proximal duct diameter, length, and percent stenosis of any stricture detected. Results: Using ERC as the standard of reference, MRC had a sensitivity and negative predictive value of 100%, mean specificity of 83.3%. and mean positive predictive value of 92.9% in the detection of six strictures. Compared with ERC, MRC obtained accurate measurements of recipient-to-donor duct diameter ratios (r, 0.91; P <0.01), proximal duct diameters (r, 0.83. P <0.05), stricture lengths (r, 0.58; P = 0.06), and percent stenosis (r, 0.78; P = 0.06). Conclusion: MRC can provide equivalent imaging to ERC and can reliably identify and quantitatively evaluate biliary strictures in post-orthotopic liver transplantation (OLT) patients.

AB - Purpose: To compare magnetic resonance cholangiography (MRC) with endoscopic retrograde cholangiography (ERC) in quantitatively evaluating biliary strictures in liver transplant recipients. Materials and Methods: Eight liver transplant recipients with suspected biliary complications were referred for ERC and also underwent MRC within 24 hours using a combination of single-shot rapid acquisition with relaxation enhancement (SS-RARE) and three-dimensional (3D)-RARE sequences. The studies were independently interpreted by two blinded radiologists and a single blinded endoscopist who recorded the presence of a stricture and/or upstream dilatation, the ratio of recipient-to-donor duct diameters at the anastomosis, as well as the proximal duct diameter, length, and percent stenosis of any stricture detected. Results: Using ERC as the standard of reference, MRC had a sensitivity and negative predictive value of 100%, mean specificity of 83.3%. and mean positive predictive value of 92.9% in the detection of six strictures. Compared with ERC, MRC obtained accurate measurements of recipient-to-donor duct diameter ratios (r, 0.91; P <0.01), proximal duct diameters (r, 0.83. P <0.05), stricture lengths (r, 0.58; P = 0.06), and percent stenosis (r, 0.78; P = 0.06). Conclusion: MRC can provide equivalent imaging to ERC and can reliably identify and quantitatively evaluate biliary strictures in post-orthotopic liver transplantation (OLT) patients.

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