Magnetic resonance approaches to brain aging and Alzheimer disease-associated neuropathology

Valerie Anderson, Zachary N. Litvack, Jeffrey Kaye

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The noninvasive, nonradioactive, quantitative nature of magnetic resonance techniques has propelled them to the forefront of neuroscience and neuropsychiatric research. In particular, recent advances have confirmed their enormous potential in patients with Alzheimer disease (AD). Structural and functional magnetic resonance (MR) imaging have demonstrated significant correlation with clinical outcomes and underlying pathology and are used increasingly in the AD clinic. This review will highlight the role of high-resolution structural MR imaging and functional magnetic resonance imaging in the identification of atrophic and hemodynamic changes in AD and their potential as diagnostic biomarkers and surrogates of therapeutic response. Advanced MR techniques based on diffusion, perfusion, and neurochemical abnormalities in the aging brain will be presented briefly. These newer techniques continue to expand our understanding of neuropathology in the aging brain and are likely to play an important clinical role in the future.

Original languageEnglish (US)
Pages (from-to)439-452
Number of pages14
JournalTopics in Magnetic Resonance Imaging
Volume16
Issue number6
DOIs
StatePublished - Dec 2005

Fingerprint

Brain Diseases
Alzheimer Disease
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Brain
Neurosciences
Perfusion
Biomarkers
Hemodynamics
Pathology
Research
Neuropathology
Therapeutics

Keywords

  • Aging
  • Alzheimer disease
  • Dementia
  • Functional
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetic resonance approaches to brain aging and Alzheimer disease-associated neuropathology. / Anderson, Valerie; Litvack, Zachary N.; Kaye, Jeffrey.

In: Topics in Magnetic Resonance Imaging, Vol. 16, No. 6, 12.2005, p. 439-452.

Research output: Contribution to journalArticle

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