Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo

William Rooney, Glyn Johnson, Xin Li, Eric R. Cohen, Seong Gi Kim, Kamil Ugurbil, Charles Jr Springer

Research output: Contribution to journalArticle

357 Citations (Scopus)

Abstract

Brain water proton (1H2O) longitudinal relaxation time constants (T1) were obtained from three healthy individuals at magnetic field strengths (B0) of 0.2 Tesla (T), 1.0T, 1.5T, 4.0T, and 7.0T. A 5-mm midventricular axial slice was sampled using a modified Look-Locker technique with 1.5 mm in-plane resolution, and 32 time points post-adiabatic inversion. The results confirmed that for most brain tissues, T1 values increased by more than a factor of 3 between 0.2T and 7T, and over this range were well fitted by T1 (s) = 0.583(B 0)0.382, T1(s) = 0.857(B0) 0.376, and T1(s) = 1.35(B0)0.340 for white matter (WM), internal GM, and blood 1H2O, respectively. The ventricular cerebrospinal fluid (CSF) 1H 2O T1 value did not change with B0, and its average value (standard deviation (SD)) across subjects and magnetic fields was 4.3 (±0.2) s. The tissue 1/T1 values at each field were well correlated with the macromolecular mass fraction, and to a lesser extent tissue iron content. The field-dependent increases in 1H2O T 1 values more than offset the well-known decrease in typical MRI contrast reagent (CR) relaxivity, and simulations predict that this leads to lower CR concentration detection thresholds with increased magnetic field.

Original languageEnglish (US)
Pages (from-to)308-318
Number of pages11
JournalMagnetic Resonance in Medicine
Volume57
Issue number2
DOIs
StatePublished - Feb 2007

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Magnetic Fields
Brain
Cerebrospinal Fluid
Protons
Iron
Water

Keywords

  • Brain
  • Magnetic field
  • MRI
  • Relaxation
  • Tissue

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo. / Rooney, William; Johnson, Glyn; Li, Xin; Cohen, Eric R.; Kim, Seong Gi; Ugurbil, Kamil; Springer, Charles Jr.

In: Magnetic Resonance in Medicine, Vol. 57, No. 2, 02.2007, p. 308-318.

Research output: Contribution to journalArticle

Rooney, William ; Johnson, Glyn ; Li, Xin ; Cohen, Eric R. ; Kim, Seong Gi ; Ugurbil, Kamil ; Springer, Charles Jr. / Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo. In: Magnetic Resonance in Medicine. 2007 ; Vol. 57, No. 2. pp. 308-318.
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