Magnesium sulfate for cerebral palsy prevention

Dwight J. Rouse; Karen J. Gibbins

doi:10.1053/j.semperi.2013.06.025

Magnesium sulfate for cerebral palsy prevention

Dwight J. Rouse, Karen J. Gibbins

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Magnesium sulfate (MgSO₄) has been shown to prevent cerebral palsy among children born to women at high risk of early preterm delivery. Three large, randomized placebo-controlled trials and a subsequent Cochrane Review suggest this intervention can decrease rates of cerebral palsy by 32% with a number needed to treat of 63 to prevent one case. Not only is MgSO₄ familiar to obstetricians, it also has an excellent safety profile. Simple protocols exist to help guide clinicians in using MgSO₄ for this indication. Evaluation of actual clinical practice shows that this use is both feasible and can be accomplished parsimoniously.

Original language	English (US)
Pages (from-to)	414-416
Number of pages	3
Journal	Seminars in Perinatology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1053/j.semperi.2013.06.025
State	Published - Dec 2013
Externally published	Yes

Keywords

Cerebral palsy
Magnesium sulfate
PPROM
Preterm birth

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1053/j.semperi.2013.06.025

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title = "Magnesium sulfate for cerebral palsy prevention",

abstract = "Magnesium sulfate (MgSO4) has been shown to prevent cerebral palsy among children born to women at high risk of early preterm delivery. Three large, randomized placebo-controlled trials and a subsequent Cochrane Review suggest this intervention can decrease rates of cerebral palsy by 32% with a number needed to treat of 63 to prevent one case. Not only is MgSO4 familiar to obstetricians, it also has an excellent safety profile. Simple protocols exist to help guide clinicians in using MgSO4 for this indication. Evaluation of actual clinical practice shows that this use is both feasible and can be accomplished parsimoniously.",

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AU - Gibbins, Karen J.

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AB - Magnesium sulfate (MgSO4) has been shown to prevent cerebral palsy among children born to women at high risk of early preterm delivery. Three large, randomized placebo-controlled trials and a subsequent Cochrane Review suggest this intervention can decrease rates of cerebral palsy by 32% with a number needed to treat of 63 to prevent one case. Not only is MgSO4 familiar to obstetricians, it also has an excellent safety profile. Simple protocols exist to help guide clinicians in using MgSO4 for this indication. Evaluation of actual clinical practice shows that this use is both feasible and can be accomplished parsimoniously.

KW - Cerebral palsy

KW - Magnesium sulfate

KW - PPROM

KW - Preterm birth

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Magnesium sulfate for cerebral palsy prevention

Abstract

Keywords

ASJC Scopus subject areas

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