Maculopathy in cynomolgus monkeys: A Correlated Fluorescein Angiographic and Ultrastructural Study

Lynette Feeney Burns, M. René Malinow, Michael Klein, Martha Neuringer

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    Maculae of seven cynomolgus macaque monkeys (Macaca fascicularis) showing abnormalities in color fundus photographs and fluorescein angiograms were studied in serial sections by light and electron microscopy and compared with three eyes without clinically visible defects in the macula. Maculae that showed hyperfluorescent nonleaking window defects showed no drusen or interruptions in the retinal pigment epithelium (RPE). Six of these monkeys had misshapen foveal depressions, all showed some degree of photoreceptor degeneration, and one had cells in Bruch's membrane. Bright yellow spots correlated with scattered RPE filled with lipid vacuoles. Shallow RPE elevations correlated with diffuse nonleaking window defects. Patches of RPE deficient in melanin occurred at sites of hyperfluorescence. Quantitative studies showed that maculae with window defects had more lipofuscin and less melanin per RPE cell. Maculae deemed normal by photography showed degenerating photoreceptors.

    Original languageEnglish (US)
    Pages (from-to)664-672
    Number of pages9
    JournalArchives of Ophthalmology
    Volume99
    Issue number4
    DOIs
    StatePublished - 1981

    Fingerprint

    Macaca fascicularis
    Retinal Pigment Epithelium
    Fluorescein
    Melanins
    Bruch Membrane
    Lipofuscin
    Photography
    Macaca
    Vacuoles
    Haplorhini
    Electron Microscopy
    Angiography
    Color
    Lipids
    Light

    ASJC Scopus subject areas

    • Ophthalmology

    Cite this

    Maculopathy in cynomolgus monkeys : A Correlated Fluorescein Angiographic and Ultrastructural Study. / Feeney Burns, Lynette; Malinow, M. René; Klein, Michael; Neuringer, Martha.

    In: Archives of Ophthalmology, Vol. 99, No. 4, 1981, p. 664-672.

    Research output: Contribution to journalArticle

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