TY - JOUR
T1 - Maculopathy in cynomolgus monkeys
T2 - A Correlated Fluorescein Angiographic and Ultrastructural Study
AU - Feeney Burns, Lynette
AU - Malinow, M. René
AU - Klein, Michael L.
AU - Neuringer, Martha
PY - 1981/4
Y1 - 1981/4
N2 - Maculae of seven cynomolgus macaque monkeys (Macaca fascicularis) showing abnormalities in color fundus photographs and fluorescein angiograms were studied in serial sections by light and electron microscopy and compared with three eyes without clinically visible defects in the macula. Maculae that showed hyperfluorescent nonleaking window defects showed no drusen or interruptions in the retinal pigment epithelium (RPE). Six of these monkeys had misshapen foveal depressions, all showed some degree of photoreceptor degeneration, and one had cells in Bruch's membrane. Bright yellow spots correlated with scattered RPE filled with lipid vacuoles. Shallow RPE elevations correlated with diffuse nonleaking window defects. Patches of RPE deficient in melanin occurred at sites of hyperfluorescence. Quantitative studies showed that maculae with window defects had more lipofuscin and less melanin per RPE cell. Maculae deemed normal by photography showed degenerating photoreceptors.
AB - Maculae of seven cynomolgus macaque monkeys (Macaca fascicularis) showing abnormalities in color fundus photographs and fluorescein angiograms were studied in serial sections by light and electron microscopy and compared with three eyes without clinically visible defects in the macula. Maculae that showed hyperfluorescent nonleaking window defects showed no drusen or interruptions in the retinal pigment epithelium (RPE). Six of these monkeys had misshapen foveal depressions, all showed some degree of photoreceptor degeneration, and one had cells in Bruch's membrane. Bright yellow spots correlated with scattered RPE filled with lipid vacuoles. Shallow RPE elevations correlated with diffuse nonleaking window defects. Patches of RPE deficient in melanin occurred at sites of hyperfluorescence. Quantitative studies showed that maculae with window defects had more lipofuscin and less melanin per RPE cell. Maculae deemed normal by photography showed degenerating photoreceptors.
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U2 - 10.1001/archopht.1981.03930010664013
DO - 10.1001/archopht.1981.03930010664013
M3 - Article
C2 - 7224938
AN - SCOPUS:0019471856
SN - 0003-9950
VL - 99
SP - 664
EP - 672
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 4
ER -