TY - JOUR
T1 - Macular perfusion in healthy chinese
T2 - An optical coherence tomography angiogram study
AU - Yu, Jian
AU - Jiang, Chunhui
AU - Wang, Xiaolei
AU - Zhu, Li
AU - Gu, Ruiping
AU - Xu, Huan
AU - Jia, Yali
AU - Huang, David
AU - Sun, Xinghuai
N1 - Publisher Copyright:
© 2015 The Association for Research in Vision and Ophthalmology, Inc.
PY - 2015
Y1 - 2015
N2 - PURPOSE. To investigate macular perfusion in healthy Chinese individuals and examine its dependence on age and sex. METHODS. Healthy adult Chinese individuals were recruited. Macular perfusion was measured by spectral-domain optical coherence tomography (OCT) using the split-spectrum amplitudedecorrelation angiography (SSADA) algorithm. The parafoveal flow index and vessel area density as well as the area of the foveal capillary-free zone (CFZ) were quantified. RESULTS. A total of 76 eyes in 45 subjects were included (20 males and 25 females, mean age 36±11 years). The mean parafoveal flow index was 0.099 ± 0.013; the mean vessel area density was 0.891 ± 0.073; and the mean CFZ area was 0.474 ± 0.172 mm2. All three parameters were significantly correlated with age (flow index: P = 0.00; vessel area density: P = 0.00; CFZ area: P = 0.02). The flow index and vessel area density decreased annually by 0.6% and 0.4%, respectively, and CFZ area increased by 1.48% annually. The CFZ area was larger in females than in males, while all three parameters seemed to change more rapidly with age in males than in females. CONCLUSIONS. In healthy Chinese eyes, macular perfusion decreased with increasing age, and decreased more rapidly in males than in females. The application of OCT angiograms may provide a useful approach for monitoring macular perfusion, although caution must be exercised with regard to age- and sex-related variations.
AB - PURPOSE. To investigate macular perfusion in healthy Chinese individuals and examine its dependence on age and sex. METHODS. Healthy adult Chinese individuals were recruited. Macular perfusion was measured by spectral-domain optical coherence tomography (OCT) using the split-spectrum amplitudedecorrelation angiography (SSADA) algorithm. The parafoveal flow index and vessel area density as well as the area of the foveal capillary-free zone (CFZ) were quantified. RESULTS. A total of 76 eyes in 45 subjects were included (20 males and 25 females, mean age 36±11 years). The mean parafoveal flow index was 0.099 ± 0.013; the mean vessel area density was 0.891 ± 0.073; and the mean CFZ area was 0.474 ± 0.172 mm2. All three parameters were significantly correlated with age (flow index: P = 0.00; vessel area density: P = 0.00; CFZ area: P = 0.02). The flow index and vessel area density decreased annually by 0.6% and 0.4%, respectively, and CFZ area increased by 1.48% annually. The CFZ area was larger in females than in males, while all three parameters seemed to change more rapidly with age in males than in females. CONCLUSIONS. In healthy Chinese eyes, macular perfusion decreased with increasing age, and decreased more rapidly in males than in females. The application of OCT angiograms may provide a useful approach for monitoring macular perfusion, although caution must be exercised with regard to age- and sex-related variations.
KW - Capillary-free zone
KW - Macular perfusion
KW - Optical coherence tomography (OCT) angiogram
KW - Split-spectrum amplitudedecorrelation angiography (SSADA) algorithm
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U2 - 10.1167/iovs.14-16270
DO - 10.1167/iovs.14-16270
M3 - Article
C2 - 26024105
AN - SCOPUS:84939804049
SN - 0146-0404
VL - 56
SP - 3212
EP - 3217
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 5
ER -