Macrophages, lipoprotein metabolism, and atherosclerosis: Insights from murine bone marrow transplantation studies

MacRae F. Linton, Sergio Fazio

    Research output: Contribution to journalReview article

    46 Scopus citations

    Abstract

    The macrophage expresses a variety of genes that may contribute to lipoprotein metabolism and atherosclerotic lesion formation. Bone marrow transplantation experiments using gene-targeted mice, both as donors and recipients, provide a useful approach to examine the contribution of macrophage gene expression to lipoprotein metabolism and atherogenesis in vivo. This article describes recent insights into the role of macrophage expression of apolipoprotein E and the LDL receptor gained from bone marrow transplantation studies in the mouse.

    Original languageEnglish (US)
    Pages (from-to)97-105
    Number of pages9
    JournalCurrent opinion in lipidology
    Volume10
    Issue number2
    DOIs
    StatePublished - Apr 1 1999

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Molecular Biology
    • Genetics
    • Nutrition and Dietetics
    • Cardiology and Cardiovascular Medicine
    • Cell Biology

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