Macrophages, lipoprotein metabolism, and atherosclerosis: Insights from murine bone marrow transplantation studies

MacRae F. Linton, Sergio Fazio

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

The macrophage expresses a variety of genes that may contribute to lipoprotein metabolism and atherosclerotic lesion formation. Bone marrow transplantation experiments using gene-targeted mice, both as donors and recipients, provide a useful approach to examine the contribution of macrophage gene expression to lipoprotein metabolism and atherogenesis in vivo. This article describes recent insights into the role of macrophage expression of apolipoprotein E and the LDL receptor gained from bone marrow transplantation studies in the mouse.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalCurrent opinion in lipidology
Volume10
Issue number2
DOIs
StatePublished - Apr 1999
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Fingerprint Dive into the research topics of 'Macrophages, lipoprotein metabolism, and atherosclerosis: Insights from murine bone marrow transplantation studies'. Together they form a unique fingerprint.

Cite this