Macrophages, lipoprotein metabolism, and atherosclerosis: Insights from murine bone marrow transplantation studies

MacRae F. Linton, Sergio Fazio

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

The macrophage expresses a variety of genes that may contribute to lipoprotein metabolism and atherosclerotic lesion formation. Bone marrow transplantation experiments using gene-targeted mice, both as donors and recipients, provide a useful approach to examine the contribution of macrophage gene expression to lipoprotein metabolism and atherogenesis in vivo. This article describes recent insights into the role of macrophage expression of apolipoprotein E and the LDL receptor gained from bone marrow transplantation studies in the mouse.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalCurrent Opinion in Lipidology
Volume10
Issue number2
DOIs
Publication statusPublished - Apr 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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