TY - JOUR
T1 - Macrophages in breast cancer
T2 - Do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer?
AU - O'Brien, Jenean
AU - Schedin, Pepper
N1 - Funding Information:
Financial Support: This work was supported in part by grants from The Avon and Mary Kay Ash Foundations, and DOD BC060531 to PS and a DOD Predoctoral Grant BC073482 to JO. J.O’Brien . P. Schedin Department of Medicine, Division of Medical Oncology, University of Colorado Denver, 12801 East 17th Avenue Aurora, Denver, CO 80045, USA
PY - 2009
Y1 - 2009
N2 - Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Recently, post-pregnancy mammary involution has been characterized as having a wound healing signature. We have proposed the involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional. Macrophage influx is one of the prominent features of the involuting gland, identifying the macrophage a potential instigator of tumor progression and a novel target for breast cancer treatment and prevention.
AB - Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Recently, post-pregnancy mammary involution has been characterized as having a wound healing signature. We have proposed the involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional. Macrophage influx is one of the prominent features of the involuting gland, identifying the macrophage a potential instigator of tumor progression and a novel target for breast cancer treatment and prevention.
KW - Arginase-1
KW - Extracellular matrix
KW - Metalloproteinases
KW - Tumor-associated macrophages
UR - http://www.scopus.com/inward/record.url?scp=67649233612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649233612&partnerID=8YFLogxK
U2 - 10.1007/s10911-009-9118-8
DO - 10.1007/s10911-009-9118-8
M3 - Article
C2 - 19350209
AN - SCOPUS:67649233612
SN - 1083-3021
VL - 14
SP - 145
EP - 157
JO - Journal of Mammary Gland Biology and Neoplasia
JF - Journal of Mammary Gland Biology and Neoplasia
IS - 2
ER -