Macrophages in breast cancer: Do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer?

Jenean O'Brien, Pepper Schedin

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Recently, post-pregnancy mammary involution has been characterized as having a wound healing signature. We have proposed the involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional. Macrophage influx is one of the prominent features of the involuting gland, identifying the macrophage a potential instigator of tumor progression and a novel target for breast cancer treatment and prevention.

Original languageEnglish (US)
Pages (from-to)145-157
Number of pages13
JournalJournal of Mammary Gland Biology and Neoplasia
Volume14
Issue number2
DOIs
StatePublished - 2009
Externally publishedYes

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Macrophages
Breast Neoplasms
Pregnancy
Wound Healing
Neoplasms
Breast
Neoplasm Metastasis
Therapeutics

Keywords

  • Arginase-1
  • Extracellular matrix
  • Metalloproteinases
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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abstract = "Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Recently, post-pregnancy mammary involution has been characterized as having a wound healing signature. We have proposed the involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional. Macrophage influx is one of the prominent features of the involuting gland, identifying the macrophage a potential instigator of tumor progression and a novel target for breast cancer treatment and prevention.",
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AB - Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Recently, post-pregnancy mammary involution has been characterized as having a wound healing signature. We have proposed the involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional. Macrophage influx is one of the prominent features of the involuting gland, identifying the macrophage a potential instigator of tumor progression and a novel target for breast cancer treatment and prevention.

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