Macronodular adrenal hyperplasia in Cushing disease

J. L. Doppman, D. L. Miller, A. J. Dwyer, T. Loughlin, L. Nieman, G. B. Cutler, G. P. Chrousos, E. Oldfield, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

68 Scopus citations


Computed tomographic (CT) scans of the adrenal glands were obtained in nine patients with Cushing disease as a result of an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma and macronodular hyperplasia of the adrenal glands. The findings were compared retrospectively with those in six patients with Cushing syndrome as a result of an autonomous adrenal adenoma and 16 with Cushing syndrome as a result of ectopic ACTH production. Seven of nine patients with macronodular adrenal hyperplasia had hyperplastic adrenal glands in addition to single or multiple focal adrenal nodules. The six patients with hypercortisolism caused by an autonomous adrenal adenoma showed atrophic (four patients) or normal (two patients) ipsilateral and contralateral adrenal glands. Fourteen of 16 patients with the ectopic ACTH syndrome had hyperplasia of the adrenal glands without nodularity, and only two had focal nodules.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
Issue number2
Publication statusPublished - 1988
Externally publishedYes


ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Doppman, J. L., Miller, D. L., Dwyer, A. J., Loughlin, T., Nieman, L., Cutler, G. B., ... Loriaux, D. L. (1988). Macronodular adrenal hyperplasia in Cushing disease. Radiology, 166(2), 347-352.