Macrolide mishap for little Miss Muffett: Fatal forty DDI: Warfarin, clarithromycin, CYP2C9

Elizabeth Pedigo

doi:10.1007/978-1-4614-7495-1_148

Macrolide mishap for little Miss Muffett: Fatal forty DDI: Warfarin, clarithromycin, CYP2C9

Elizabeth Pedigo

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This case discusses the pharmacokinetic interaction of warfarin and clarithromycin leading to enhanced anticoagulant effect and elevated INR. Warfarin is a cytochrome P450 2C9 substrate and clarithromycin is a 2C9 inhibitor. The use of warfarin for pediatric patients is also discussed.

Original language	English (US)
Title of host publication	A Case Approach to Perioperative Drug-Drug Interactions
Publisher	Springer New York
Pages	665-667
Number of pages	3
ISBN (Electronic)	9781461474951
ISBN (Print)	9781461474944
DOIs	https://doi.org/10.1007/978-1-4614-7495-1_148
State	Published - Sep 15 2015
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-7495-1_148

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Macrolide mishap for little Miss Muffett: Fatal forty DDI: Warfarin, clarithromycin, CYP2C9

Abstract

ASJC Scopus subject areas

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