Macrolide mishap for little Miss Muffett: Fatal forty DDI: Warfarin, clarithromycin, CYP2C9

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses the pharmacokinetic interaction of warfarin and clarithromycin leading to enhanced anticoagulant effect and elevated INR. Warfarin is a cytochrome P450 2C9 substrate and clarithromycin is a 2C9 inhibitor. The use of warfarin for pediatric patients is also discussed.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages665-667
Number of pages3
ISBN (Electronic)9781461474951
ISBN (Print)9781461474944
DOIs
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • Medicine(all)

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