Machine Learning Prediction of Liver Allograft Utilization from Deceased Organ Donors Using the National Donor Management Goals Registry

Andrew M. Bishara, Dmytro S. Lituiev, Dieter Adelmann, Rishi P. Kothari, Darren J. Malinoski, Jacob D. Nudel, Mitchell Sally, Ryutaro Hirose, Dexter D. Hadley, Claus U. Niemann

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Early prediction of whether a liver allograft will be utilized for transplantation may allow better resource deployment during donor management and improve organ allocation. The national donor management goals (DMG) registry contains critical care data collected during donor management. We developed a machine learning model to predict transplantation of a liver graft based on data from the DMG registry. Methods. Several machine learning classifiers were trained to predict transplantation of a liver graft. We utilized 127 variables available in the DMG dataset. We included data from potential deceased organ donors between April 2012 and January 2019. The outcome was defined as liver recovery for transplantation in the operating room. The prediction was made based on data available 12-18 h after the time of authorization for transplantation. The data were randomly separated into training (60%), validation (20%), and test sets (20%). We compared the performance of our models to the Liver Discard Risk Index. Results. Of 13 629 donors in the dataset, 9255 (68%) livers were recovered and transplanted, 1519 recovered but used for research or discarded, 2855 were not recovered. The optimized gradient boosting machine classifier achieved an area under the curve of the receiver operator characteristic of 0.84 on the test set, outperforming all other classifiers. Conclusions. This model predicts successful liver recovery for transplantation in the operating room, using data available early during donor management. It performs favorably when compared to existing models. It may provide real-time decision support during organ donor management and transplant logistics.

Original languageEnglish (US)
Article number01212
JournalTransplantation Direct
DOIs
StateAccepted/In press - 2021

ASJC Scopus subject areas

  • Transplantation

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