MACH14: A multi-site collaboration on ART adherence among 14 institutions

Honghu Liu, Ira B. Wilson, Kathy Goggin, Nancy Reynolds, Jane M. Simoni, Carol E. Golin, Marc I. Rosen, Robert Gross, Glenn Wagner, Robert H. Remien, Neil Schneiderman, Judith A. Erlen, Julia H. Arnsten, David Bangsberg

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a large data system has been created for integrated analyses by pooling original data from 16 longitudinal ARV adherence studies. Studies selected met specific criteria including similar research design and data domains such as adherence measured with medication event monitoring system, psychosocial factors related to adherence behavior, and virologic and clinical outcomes. The data system created contains individual data (collected between 1997 and 2009) from 2,860 HIV patients. Collaboration helped resolve the challenges inherent in pooling data across multiple studies, yet produced a data system with strong statistical power and potentially greater capacity to address key scientific questions than possible with single-sample studies or even meta-analytic designs.

Original languageEnglish (US)
Pages (from-to)127-141
Number of pages15
JournalAIDS and Behavior
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

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Keywords

  • Adherence
  • Antiretroviral medication
  • HIV/AIDS
  • Individual participant data
  • MEMS
  • Multi-site

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

Cite this

Liu, H., Wilson, I. B., Goggin, K., Reynolds, N., Simoni, J. M., Golin, C. E., ... Bangsberg, D. (2013). MACH14: A multi-site collaboration on ART adherence among 14 institutions. AIDS and Behavior, 17(1), 127-141. https://doi.org/10.1007/s10461-012-0272-4