Lysophosphatidic acid production and action: Critical new players in breast cancer initiation and progression

N. Panupinthu, H. Y. Lee, G. B. Mills

Research output: Contribution to journalShort survey

85 Scopus citations

Abstract

Lysophosphatidic acid (LPA) is a potent lipid mediator that acts on a series of specific G protein-coupled receptors, leading to diverse biological actions. Lysophosphatidic acid induces cell proliferation, survival and migration, which are critically required for tumour formation and metastasis. This bioactive lipid is produced by the ectoenzyme lysophospholipase D or autotaxin (ATX), earlier known as an autocrine motility factor. The ATX-LPA signalling axis has emerged as an important player in many types of cancer. Indeed, aberrant expression of ATX and LPA receptors occurs during the development and progression of breast cancer. Importantly, expression of either ATX or LPA receptors in the mammary gland of transgenic mice is sufficient to induce the development of a high frequency of invasive and metastatic mammary cancers. The focus of research now turns to understanding the mechanisms by which ATX and LPA promote mammary tumourigenesis and metastasis. Targeting the ATX-LPA signalling axis for drug development may further improve outcomes in patients with breast cancer.

Original languageEnglish (US)
Pages (from-to)941-946
Number of pages6
JournalBritish Journal of Cancer
Volume102
Issue number6
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • Autotaxin
  • Breast cancer
  • G protein-coupled receptor
  • Inflammation
  • Lysophosphatidic acid

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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