Abstract
Lymphocytic colitis is a subtype of microscopic colitis that is mostly seen in adults. It presents mainly as chronic nonbloody diarrhea, with the hallmark of normal or near-normal endoscopy. In this case series, we are presenting 4 pediatric patients with lymphocytic colitis with prominent apoptosis of the colonic gland epithelium. Remarkably, all the patients have genetic mutations known to be associated with autoimmune enteropathy. Three patients have a CTLA4 mutation, and 1 patient has an STAT3 mutation. These mutations were previously reported in association with inflammatory bowel disease, but a specific connection with lymphocytic colitis has not been described. This report investigates the histopathology of such lesions in children and adolescents.
Original language | English (US) |
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Pages (from-to) | 443-447 |
Number of pages | 5 |
Journal | Pediatric and Developmental Pathology |
Volume | 23 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2020 |
Externally published | Yes |
Keywords
- CTLA4
- STAT3
- apoptosis
- apoptotic colopathy
- colitis
- lymphocytic colitis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pathology and Forensic Medicine