TY - JOUR
T1 - Lymphocyte vaccination again t experimental autoimmune encephalomyelitis
T2 - evaluation of vaccination protocols
AU - Offner, Halina
AU - Jones, Richard
AU - Celnik, Bozena
AU - Vandenbark, Arthur A.
N1 - Funding Information:
Experimental autoimmune encephalomyelitis (EAE) is an organ-specific autoimmune disease of the central nervous system (CNS) in a variety of Address for correspondence: Halina Offner, Ph.D.. Neuro-immunology Research 151D, Veterans Administration Medical Center, Portland, OR 97201, U.S.A. This research was supported by the Veterans Administration and NIH grants IQS23221 and NS23444.
PY - 1989/1
Y1 - 1989/1
N2 - Repeated vaccination with encephalitogenic but not other T cell lines could effect marked resistance to 'active' experimental autoimmune encephalomyelitis (EAE) induced by injection of GP-BP in adjuvant. Partial resistance to active EAE was observed in rats recovered from 'passive' line-mediated EAE and in rats vaccinated with T cells attenuated by irradiation or ganglioside treatment. However, no resistance was observed in animals given low doses of activated encephalitogenic T cells. Treatment with hydrostatic pressure alone was found to be ineffective as a means of attenuation, and vaccination with pressure-treated encephalitogenic T cells actually induced mild signs of EAE. However, vaccination with cells that were first pressure treated and then irradiated prevented both clinical and histologic signs of active EAE. In contrast, protection against passive EAE appeared to be clonotypic. Lymphocyte vaccination induced delayed type hypersensitivity (DTH) reactions against autologous T cells, mostly to shared antigens, demonstrating the immunogenicity of multiple antigens on the vaccinating cells.
AB - Repeated vaccination with encephalitogenic but not other T cell lines could effect marked resistance to 'active' experimental autoimmune encephalomyelitis (EAE) induced by injection of GP-BP in adjuvant. Partial resistance to active EAE was observed in rats recovered from 'passive' line-mediated EAE and in rats vaccinated with T cells attenuated by irradiation or ganglioside treatment. However, no resistance was observed in animals given low doses of activated encephalitogenic T cells. Treatment with hydrostatic pressure alone was found to be ineffective as a means of attenuation, and vaccination with pressure-treated encephalitogenic T cells actually induced mild signs of EAE. However, vaccination with cells that were first pressure treated and then irradiated prevented both clinical and histologic signs of active EAE. In contrast, protection against passive EAE appeared to be clonotypic. Lymphocyte vaccination induced delayed type hypersensitivity (DTH) reactions against autologous T cells, mostly to shared antigens, demonstrating the immunogenicity of multiple antigens on the vaccinating cells.
KW - (Lewis rat)
KW - Experimental autoimmune encephalomyelitis
KW - Lymphocyte vaccination
KW - Vaccination protocol
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U2 - 10.1016/0165-5728(89)90154-9
DO - 10.1016/0165-5728(89)90154-9
M3 - Article
C2 - 2521179
AN - SCOPUS:0024534367
SN - 0165-5728
VL - 21
SP - 13
EP - 22
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1
ER -