Lymphocyte vaccination again t experimental autoimmune encephalomyelitis: evaluation of vaccination protocols

Halina Offner, Richard Jones, Bozena Celnik, Arthur Vandenbark

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Abstract

Repeated vaccination with encephalitogenic but not other T cell lines could effect marked resistance to 'active' experimental autoimmune encephalomyelitis (EAE) induced by injection of GP-BP in adjuvant. Partial resistance to active EAE was observed in rats recovered from 'passive' line-mediated EAE and in rats vaccinated with T cells attenuated by irradiation or ganglioside treatment. However, no resistance was observed in animals given low doses of activated encephalitogenic T cells. Treatment with hydrostatic pressure alone was found to be ineffective as a means of attenuation, and vaccination with pressure-treated encephalitogenic T cells actually induced mild signs of EAE. However, vaccination with cells that were first pressure treated and then irradiated prevented both clinical and histologic signs of active EAE. In contrast, protection against passive EAE appeared to be clonotypic. Lymphocyte vaccination induced delayed type hypersensitivity (DTH) reactions against autologous T cells, mostly to shared antigens, demonstrating the immunogenicity of multiple antigens on the vaccinating cells.

Original languageEnglish (US)
Pages (from-to)13-22
Number of pages10
JournalJournal of Neuroimmunology
Volume21
Issue number1
DOIs
Publication statusPublished - 1989

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Keywords

  • (Lewis rat)
  • Experimental autoimmune encephalomyelitis
  • Lymphocyte vaccination
  • Vaccination protocol

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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