Lymphocyte stimulation in multiple sclerosis patients untreated and treated with transfer factor. Long-term studies on the effect of different stimulants on myo-(2- 3H)inositol incorporation into phosphatidylinositol of lymphocytes

Halina Offner, N. E. Raun, G. Konat, T. Fog, J. Clausen

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4 Scopus citations


The lymphocytes from controls, untreated MS and MS patients treated with transfer factor were stimulated with PHA, PWM, PPD, LPS and MA and the increased incorporation of myoinositol into phosphatidylinositides was determined. As compared with controls, the untreated MS patents revealed significantly lower index of stimulation with PHA, LPS, PPD and MA. The response of lymphocytes from MS patients treated with transfer factor was intermediate. No correlation between disease progression and stimulation of inositol incorporation was observed. Analysis of variance showed that the myoinositol test is not applicable in long-term studies to distinguish single subjects, however it is useful to determine differences between MS patients and controls.

Original languageEnglish (US)
Pages (from-to)465-474
Number of pages10
JournalActa Neurologica Scandinavica
Issue number6
Publication statusPublished - 1977
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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