Lymphocyte homing and homeostasis

Eugene C. Butcher, Louis J. Picker

Research output: Contribution to journalArticle

2414 Scopus citations

Abstract

The integration and control of systemic immune responses depends on the regulated trafficking of lymphocytes. This lymphocyte 'homing' process disperses the immunologic repertoire, directs lymphocyte subsets to the specialized microenvironments that control their differentiation and regulate their survival, and targets immune effector cells to sites of antigenic or microbial invasion. Recent advances reveal that the exquisite specificity of lymphocyte homing is determined by combinatorial 'decision processes' involving multistep sequential engagement of adhesion and signaling receptors. These homing-related interactions are seamlessly integrated into the overall interaction of the lymphocyte with its environment and participate directly in the control of lymphocyte function, life-span, and population dynamics. In this article a review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulates the homeostasis of immunologic resources are proposed.

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
JournalScience
Volume272
Issue number5258
DOIs
StatePublished - Apr 5 1996

ASJC Scopus subject areas

  • General

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