Abstract
Mechanisms leading to the observed immune dysregulation in chronic HIV infection are not well understood. The MHC-II class ligand, lymphocyte activation gene-3 (LAG-3, CD223), has been implicated in the complex regulation mechanism of immune functions. In this study, we describe a new population of HIV-specific CD8+ T cells expressing LAG-3. These LAG-3 +CD8+ T cells do not display immunophenotypic patterns traditionally attributed to regulatory T cells. The LAG3+CD8 + T cells are CCR7+,CD127-, and display heterogeneous surface expressions of CD45RA and CD25. Interestingly, HIV-specific LAG-3+CD8+ T cells do not substantially express CTLA-4 and LAG-3 expression does not correlate with interleukin (IL)-10 or tumor growth factor (TGF)-β production. In addition, HIV-specific LAG3+CD8+ T cells do not produce interferon (IFN-γ) or express CD107a. The frequency of HIV-specific LAG3+CD8+ T cells negative correlated with plasma viral load. Our study introduces a new population of HIV-specific CD8+ T cells and proposes additional mechanisms of immune regulation in chronic HIV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 535-541 |
| Number of pages | 7 |
| Journal | AIDS Research and Human Retroviruses |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2014 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Virology
- Infectious Diseases
- Medicine(all)
Cite this
Lymphocyte activation gene-3 expression defines a discrete subset of HIV-Specific CD8+ T cells that is associated with Lower Viral Load. / Peña, José; Jones, Norman G.; Bousheri, Stephanie; Bangsberg, David; Cao, Huyen.
In: AIDS Research and Human Retroviruses, Vol. 30, No. 6, 01.06.2014, p. 535-541.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphocyte activation gene-3 expression defines a discrete subset of HIV-Specific CD8+ T cells that is associated with Lower Viral Load
AU - Peña, José
AU - Jones, Norman G.
AU - Bousheri, Stephanie
AU - Bangsberg, David
AU - Cao, Huyen
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Mechanisms leading to the observed immune dysregulation in chronic HIV infection are not well understood. The MHC-II class ligand, lymphocyte activation gene-3 (LAG-3, CD223), has been implicated in the complex regulation mechanism of immune functions. In this study, we describe a new population of HIV-specific CD8+ T cells expressing LAG-3. These LAG-3 +CD8+ T cells do not display immunophenotypic patterns traditionally attributed to regulatory T cells. The LAG3+CD8 + T cells are CCR7+,CD127-, and display heterogeneous surface expressions of CD45RA and CD25. Interestingly, HIV-specific LAG-3+CD8+ T cells do not substantially express CTLA-4 and LAG-3 expression does not correlate with interleukin (IL)-10 or tumor growth factor (TGF)-β production. In addition, HIV-specific LAG3+CD8+ T cells do not produce interferon (IFN-γ) or express CD107a. The frequency of HIV-specific LAG3+CD8+ T cells negative correlated with plasma viral load. Our study introduces a new population of HIV-specific CD8+ T cells and proposes additional mechanisms of immune regulation in chronic HIV infection.
AB - Mechanisms leading to the observed immune dysregulation in chronic HIV infection are not well understood. The MHC-II class ligand, lymphocyte activation gene-3 (LAG-3, CD223), has been implicated in the complex regulation mechanism of immune functions. In this study, we describe a new population of HIV-specific CD8+ T cells expressing LAG-3. These LAG-3 +CD8+ T cells do not display immunophenotypic patterns traditionally attributed to regulatory T cells. The LAG3+CD8 + T cells are CCR7+,CD127-, and display heterogeneous surface expressions of CD45RA and CD25. Interestingly, HIV-specific LAG-3+CD8+ T cells do not substantially express CTLA-4 and LAG-3 expression does not correlate with interleukin (IL)-10 or tumor growth factor (TGF)-β production. In addition, HIV-specific LAG3+CD8+ T cells do not produce interferon (IFN-γ) or express CD107a. The frequency of HIV-specific LAG3+CD8+ T cells negative correlated with plasma viral load. Our study introduces a new population of HIV-specific CD8+ T cells and proposes additional mechanisms of immune regulation in chronic HIV infection.
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U2 - 10.1089/aid.2012.0195
DO - 10.1089/aid.2012.0195
M3 - Article
VL - 30
SP - 535
EP - 541
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 6
ER -