Lymphocyte activation gene-3 expression defines a discrete subset of HIV-Specific CD8+ T cells that is associated with Lower Viral Load

José Peña, Norman G. Jones, Stephanie Bousheri, David Bangsberg, Huyen Cao

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mechanisms leading to the observed immune dysregulation in chronic HIV infection are not well understood. The MHC-II class ligand, lymphocyte activation gene-3 (LAG-3, CD223), has been implicated in the complex regulation mechanism of immune functions. In this study, we describe a new population of HIV-specific CD8+ T cells expressing LAG-3. These LAG-3 +CD8+ T cells do not display immunophenotypic patterns traditionally attributed to regulatory T cells. The LAG3+CD8 + T cells are CCR7+,CD127-, and display heterogeneous surface expressions of CD45RA and CD25. Interestingly, HIV-specific LAG-3+CD8+ T cells do not substantially express CTLA-4 and LAG-3 expression does not correlate with interleukin (IL)-10 or tumor growth factor (TGF)-β production. In addition, HIV-specific LAG3+CD8+ T cells do not produce interferon (IFN-γ) or express CD107a. The frequency of HIV-specific LAG3+CD8+ T cells negative correlated with plasma viral load. Our study introduces a new population of HIV-specific CD8+ T cells and proposes additional mechanisms of immune regulation in chronic HIV infection.

Original languageEnglish (US)
Pages (from-to)535-541
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume30
Issue number6
DOIs
StatePublished - Jun 1 2014
Externally publishedYes

Fingerprint

Lymphocyte Activation
Viral Load
HIV
T-Lymphocytes
Gene Expression
HIV Infections
Regulatory T-Lymphocytes
Interleukin-10
Interferons
Population
Intercellular Signaling Peptides and Proteins
Ligands
Genes
Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases
  • Medicine(all)

Cite this

Lymphocyte activation gene-3 expression defines a discrete subset of HIV-Specific CD8+ T cells that is associated with Lower Viral Load. / Peña, José; Jones, Norman G.; Bousheri, Stephanie; Bangsberg, David; Cao, Huyen.

In: AIDS Research and Human Retroviruses, Vol. 30, No. 6, 01.06.2014, p. 535-541.

Research output: Contribution to journalArticle

@article{77bbd85932e8414895d67194110170d0,
title = "Lymphocyte activation gene-3 expression defines a discrete subset of HIV-Specific CD8+ T cells that is associated with Lower Viral Load",
abstract = "Mechanisms leading to the observed immune dysregulation in chronic HIV infection are not well understood. The MHC-II class ligand, lymphocyte activation gene-3 (LAG-3, CD223), has been implicated in the complex regulation mechanism of immune functions. In this study, we describe a new population of HIV-specific CD8+ T cells expressing LAG-3. These LAG-3 +CD8+ T cells do not display immunophenotypic patterns traditionally attributed to regulatory T cells. The LAG3+CD8 + T cells are CCR7+,CD127-, and display heterogeneous surface expressions of CD45RA and CD25. Interestingly, HIV-specific LAG-3+CD8+ T cells do not substantially express CTLA-4 and LAG-3 expression does not correlate with interleukin (IL)-10 or tumor growth factor (TGF)-β production. In addition, HIV-specific LAG3+CD8+ T cells do not produce interferon (IFN-γ) or express CD107a. The frequency of HIV-specific LAG3+CD8+ T cells negative correlated with plasma viral load. Our study introduces a new population of HIV-specific CD8+ T cells and proposes additional mechanisms of immune regulation in chronic HIV infection.",
author = "Jos{\'e} Pe{\~n}a and Jones, {Norman G.} and Stephanie Bousheri and David Bangsberg and Huyen Cao",
year = "2014",
month = "6",
day = "1",
doi = "10.1089/aid.2012.0195",
language = "English (US)",
volume = "30",
pages = "535--541",
journal = "AIDS Research and Human Retroviruses",
issn = "0889-2229",
publisher = "Mary Ann Liebert Inc.",
number = "6",

}

TY - JOUR

T1 - Lymphocyte activation gene-3 expression defines a discrete subset of HIV-Specific CD8+ T cells that is associated with Lower Viral Load

AU - Peña, José

AU - Jones, Norman G.

AU - Bousheri, Stephanie

AU - Bangsberg, David

AU - Cao, Huyen

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Mechanisms leading to the observed immune dysregulation in chronic HIV infection are not well understood. The MHC-II class ligand, lymphocyte activation gene-3 (LAG-3, CD223), has been implicated in the complex regulation mechanism of immune functions. In this study, we describe a new population of HIV-specific CD8+ T cells expressing LAG-3. These LAG-3 +CD8+ T cells do not display immunophenotypic patterns traditionally attributed to regulatory T cells. The LAG3+CD8 + T cells are CCR7+,CD127-, and display heterogeneous surface expressions of CD45RA and CD25. Interestingly, HIV-specific LAG-3+CD8+ T cells do not substantially express CTLA-4 and LAG-3 expression does not correlate with interleukin (IL)-10 or tumor growth factor (TGF)-β production. In addition, HIV-specific LAG3+CD8+ T cells do not produce interferon (IFN-γ) or express CD107a. The frequency of HIV-specific LAG3+CD8+ T cells negative correlated with plasma viral load. Our study introduces a new population of HIV-specific CD8+ T cells and proposes additional mechanisms of immune regulation in chronic HIV infection.

AB - Mechanisms leading to the observed immune dysregulation in chronic HIV infection are not well understood. The MHC-II class ligand, lymphocyte activation gene-3 (LAG-3, CD223), has been implicated in the complex regulation mechanism of immune functions. In this study, we describe a new population of HIV-specific CD8+ T cells expressing LAG-3. These LAG-3 +CD8+ T cells do not display immunophenotypic patterns traditionally attributed to regulatory T cells. The LAG3+CD8 + T cells are CCR7+,CD127-, and display heterogeneous surface expressions of CD45RA and CD25. Interestingly, HIV-specific LAG-3+CD8+ T cells do not substantially express CTLA-4 and LAG-3 expression does not correlate with interleukin (IL)-10 or tumor growth factor (TGF)-β production. In addition, HIV-specific LAG3+CD8+ T cells do not produce interferon (IFN-γ) or express CD107a. The frequency of HIV-specific LAG3+CD8+ T cells negative correlated with plasma viral load. Our study introduces a new population of HIV-specific CD8+ T cells and proposes additional mechanisms of immune regulation in chronic HIV infection.

UR - http://www.scopus.com/inward/record.url?scp=84902186819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902186819&partnerID=8YFLogxK

U2 - 10.1089/aid.2012.0195

DO - 10.1089/aid.2012.0195

M3 - Article

VL - 30

SP - 535

EP - 541

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 6

ER -