Lymph node metastasis in melanoma: a debate on the significance of nodal metastases, conditional survival analysis and clinical trials

Mark B. Faries; Dale Han; Michael Reintgen; Lauren Kerivan; Douglas Reintgen; Corrado Caracò

doi:10.1007/s10585-018-9898-6

Lymph node metastasis in melanoma: a debate on the significance of nodal metastases, conditional survival analysis and clinical trials

Mark B. Faries, Dale Han, Michael Reintgen, Lauren Kerivan, Douglas Reintgen, Corrado Caracò

Surgery

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16 Scopus citations

Abstract

While there is no doubt that regional lymph node metastases are an enormously important factor in melanoma staging and treatment, the biology behind this significance and its precise implications for treatment planning have been a leading controversy in melanoma and other solid tumors for over a century. Recent clinical data, including data from prospective randomized clinical trials have refined our understanding of the process of nodal metastases and the advantages and disadvantages of different clinical management strategies. This review presents two points of view in this debate and discusses the results of new data analyses as well as pivotal clinical trials informing the discussion.

Original language	English (US)
Pages (from-to)	431-442
Number of pages	12
Journal	Clinical and Experimental Metastasis
Volume	35
Issue number	5-6
DOIs	https://doi.org/10.1007/s10585-018-9898-6
State	Published - Aug 1 2018

Keywords

Clinical trial
Lymphatic mapping
Melanoma
Sentinel lymph node
Surgical oncology

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10585-018-9898-6

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title = "Lymph node metastasis in melanoma: a debate on the significance of nodal metastases, conditional survival analysis and clinical trials",

abstract = "While there is no doubt that regional lymph node metastases are an enormously important factor in melanoma staging and treatment, the biology behind this significance and its precise implications for treatment planning have been a leading controversy in melanoma and other solid tumors for over a century. Recent clinical data, including data from prospective randomized clinical trials have refined our understanding of the process of nodal metastases and the advantages and disadvantages of different clinical management strategies. This review presents two points of view in this debate and discusses the results of new data analyses as well as pivotal clinical trials informing the discussion.",

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AU - Faries, Mark B.

AU - Han, Dale

AU - Reintgen, Michael

AU - Kerivan, Lauren

AU - Reintgen, Douglas

AU - Caracò, Corrado

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AB - While there is no doubt that regional lymph node metastases are an enormously important factor in melanoma staging and treatment, the biology behind this significance and its precise implications for treatment planning have been a leading controversy in melanoma and other solid tumors for over a century. Recent clinical data, including data from prospective randomized clinical trials have refined our understanding of the process of nodal metastases and the advantages and disadvantages of different clinical management strategies. This review presents two points of view in this debate and discusses the results of new data analyses as well as pivotal clinical trials informing the discussion.

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KW - Lymphatic mapping

KW - Melanoma

KW - Sentinel lymph node

KW - Surgical oncology

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Lymph node metastasis in melanoma: a debate on the significance of nodal metastases, conditional survival analysis and clinical trials

Abstract

Keywords

ASJC Scopus subject areas

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