Luteal function following ovarian stimulation in rhesus monkeys for in vitro fertilization

Atypical response to human chorionic gonadotropin treatment simulating early pregnancy

C. A. VandeVoort, David Hess, Richard Stouffer

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    13 Citations (Scopus)

    Abstract

    This study determined if corpora lutea of hyperstimulated cycles in rhesus monkeys could be 'rescued' by the pregnancy signal, chorionic gonadotropin (CG), given at the typical time of implantation. At menses, female monkeys received human follicle-stimulating hormone (hFSH, 60 IU, days 1 to 6) followed by human menopausal gonadotropin (hMG, 60 IU hFSH/60 IU luteinizing hormone [hLH], days 7 to 9). On day 10, human chorionic gonadotropin (hCG) was given to mimic the LH surge. Nine days later, a regimen of daily increasing doses of hCG (15 to 360 IU twice a day) was initiated to simulate rescue of the corpus luteum in early pregnancy. Serum levels of progesterone (P) increased through day 5 of the luteal phase but then declined. Circulating levels of bioactive LH were signficantly less on days 7 to 9 of the luteal phase than at this stage in the natural cycle. The hCG regimen extended (P <0.05) the luteal phase in five of six animals. The hCG treatment elicited a persistent increase (P <0.05) in circulating P levels, rather than a transient rise typical of normal or simulated pregnancy in natural cycles. The authors conclude that (1) corpora lutea of hyperstimulated cycles can respond to CG, but (2) there are differences in luteal function during both the luteal phase and simulated early pregnancy that may be due to inadequate luteal development or the abnormal gonadotropin milieu existing after ovulation or both.

    Original languageEnglish (US)
    Pages (from-to)1071-1075
    Number of pages5
    JournalFertility and Sterility
    Volume49
    Issue number6
    StatePublished - 1988

    Fingerprint

    Ovulation Induction
    Corpus Luteum
    Chorionic Gonadotropin
    Fertilization in Vitro
    Macaca mulatta
    Luteal Phase
    Human Follicle Stimulating Hormone
    Pregnancy
    Therapeutics
    Menotropins
    Menstruation
    Luteinizing Hormone
    Ovulation
    Gonadotropins
    Haplorhini
    Progesterone
    Serum

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

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    title = "Luteal function following ovarian stimulation in rhesus monkeys for in vitro fertilization: Atypical response to human chorionic gonadotropin treatment simulating early pregnancy",
    abstract = "This study determined if corpora lutea of hyperstimulated cycles in rhesus monkeys could be 'rescued' by the pregnancy signal, chorionic gonadotropin (CG), given at the typical time of implantation. At menses, female monkeys received human follicle-stimulating hormone (hFSH, 60 IU, days 1 to 6) followed by human menopausal gonadotropin (hMG, 60 IU hFSH/60 IU luteinizing hormone [hLH], days 7 to 9). On day 10, human chorionic gonadotropin (hCG) was given to mimic the LH surge. Nine days later, a regimen of daily increasing doses of hCG (15 to 360 IU twice a day) was initiated to simulate rescue of the corpus luteum in early pregnancy. Serum levels of progesterone (P) increased through day 5 of the luteal phase but then declined. Circulating levels of bioactive LH were signficantly less on days 7 to 9 of the luteal phase than at this stage in the natural cycle. The hCG regimen extended (P <0.05) the luteal phase in five of six animals. The hCG treatment elicited a persistent increase (P <0.05) in circulating P levels, rather than a transient rise typical of normal or simulated pregnancy in natural cycles. The authors conclude that (1) corpora lutea of hyperstimulated cycles can respond to CG, but (2) there are differences in luteal function during both the luteal phase and simulated early pregnancy that may be due to inadequate luteal development or the abnormal gonadotropin milieu existing after ovulation or both.",
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    T1 - Luteal function following ovarian stimulation in rhesus monkeys for in vitro fertilization

    T2 - Atypical response to human chorionic gonadotropin treatment simulating early pregnancy

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    AU - Hess, David

    AU - Stouffer, Richard

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    N2 - This study determined if corpora lutea of hyperstimulated cycles in rhesus monkeys could be 'rescued' by the pregnancy signal, chorionic gonadotropin (CG), given at the typical time of implantation. At menses, female monkeys received human follicle-stimulating hormone (hFSH, 60 IU, days 1 to 6) followed by human menopausal gonadotropin (hMG, 60 IU hFSH/60 IU luteinizing hormone [hLH], days 7 to 9). On day 10, human chorionic gonadotropin (hCG) was given to mimic the LH surge. Nine days later, a regimen of daily increasing doses of hCG (15 to 360 IU twice a day) was initiated to simulate rescue of the corpus luteum in early pregnancy. Serum levels of progesterone (P) increased through day 5 of the luteal phase but then declined. Circulating levels of bioactive LH were signficantly less on days 7 to 9 of the luteal phase than at this stage in the natural cycle. The hCG regimen extended (P <0.05) the luteal phase in five of six animals. The hCG treatment elicited a persistent increase (P <0.05) in circulating P levels, rather than a transient rise typical of normal or simulated pregnancy in natural cycles. The authors conclude that (1) corpora lutea of hyperstimulated cycles can respond to CG, but (2) there are differences in luteal function during both the luteal phase and simulated early pregnancy that may be due to inadequate luteal development or the abnormal gonadotropin milieu existing after ovulation or both.

    AB - This study determined if corpora lutea of hyperstimulated cycles in rhesus monkeys could be 'rescued' by the pregnancy signal, chorionic gonadotropin (CG), given at the typical time of implantation. At menses, female monkeys received human follicle-stimulating hormone (hFSH, 60 IU, days 1 to 6) followed by human menopausal gonadotropin (hMG, 60 IU hFSH/60 IU luteinizing hormone [hLH], days 7 to 9). On day 10, human chorionic gonadotropin (hCG) was given to mimic the LH surge. Nine days later, a regimen of daily increasing doses of hCG (15 to 360 IU twice a day) was initiated to simulate rescue of the corpus luteum in early pregnancy. Serum levels of progesterone (P) increased through day 5 of the luteal phase but then declined. Circulating levels of bioactive LH were signficantly less on days 7 to 9 of the luteal phase than at this stage in the natural cycle. The hCG regimen extended (P <0.05) the luteal phase in five of six animals. The hCG treatment elicited a persistent increase (P <0.05) in circulating P levels, rather than a transient rise typical of normal or simulated pregnancy in natural cycles. The authors conclude that (1) corpora lutea of hyperstimulated cycles can respond to CG, but (2) there are differences in luteal function during both the luteal phase and simulated early pregnancy that may be due to inadequate luteal development or the abnormal gonadotropin milieu existing after ovulation or both.

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