Luliconazole for the treatment of interdigital tinea pedis: A double-blind, vehicle-controlled study

Michael Jarratt, Terry Jones, Steven Kempers, Phoebe Rich, Katy Morton, Norifumi Nakamura, Amir Tavakkol

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Tinea pedis (TP) typically is treated with topical antifungal agents. Luliconazole, a novel imidazole drug, is shown to be as or more effective in vitro and in vivo than bifonazole, terbinafine, and lanoconazole. Two treatment durations with luliconazole cream 1% were evaluated for treatment of TP. Participants with interdigital TP were randomized (N=147) and treated with either luliconazole or its vehicle for either 2 or 4 weeks. The primary efficacy end point was the proportion of participants achieving complete clearance 2 weeks following completion of treatment. In the 2-week active treatment group, complete clearance was achieved in 26.8% (11/41) of participants versus 9.1% (2/22) in the 2-week vehicle group at 2-weeks posttreatment. In the 4-week active treatment group, 45.7% (16/35) achieved complete clearance versus 10.0% (2/20) in the 4-week vehicle group at 2-weeks posttreatment. Twenty-three adverse events (AEs) were reported; most were mild (56.5% [13/23]) to moderate (26.1% [6/23]) in severity. All reported AEs were determined to be unrelated (78.3% [18/23]) or unlikely related (21.7% [5/23]) to the study medication. The results of this study indicate that luliconazole cream 1% applied once daily for either 2 or 4 weeks is safe and effective for treatment of TP. More importantly, the antifungal effects of luliconazole persist for several weeks, resulting in increased rates of mycological cure.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalCutis
Volume91
Issue number4
StatePublished - Aug 22 2013

ASJC Scopus subject areas

  • Dermatology

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    Jarratt, M., Jones, T., Kempers, S., Rich, P., Morton, K., Nakamura, N., & Tavakkol, A. (2013). Luliconazole for the treatment of interdigital tinea pedis: A double-blind, vehicle-controlled study. Cutis, 91(4), 203-210.