LRRK2 pathobiology in Parkinson's disease – virtual inclusion

Ian Martin, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson

Research output: Contribution to journalComment/debate

2 Scopus citations

Abstract

A common cause of Parkinson disease are missense mutations in the leucine-rich repeat kinase 2 (LRRK2) catalytic Roc-COR domain, leading to a decrease in GTPase activity; and its kinase domain, leading to an increase in kinase activity and subsequent LRRK2 toxicity. Targeting LRRK2 with selective, brain-permeable kinase inhibitors is a promising approach to reduce toxicity, and thus is a major goal of clinical development. Understanding the specific signaling cascades triggered by LRRK2 mutations will be key to this aim. This article is part of a special issue on Parkinson disease.

Original languageEnglish (US)
Pages (from-to)75-76
Number of pages2
JournalJournal of Neurochemistry
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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