Lower sulfurtransferase detoxification rates of cyanide in konzo-A tropical spastic paralysis linked to cassava cyanogenic poisoning

K. J. Kambale, E. R. Ali, N. H. Sadiki, K. P. Kayembe, L. G. Mvumbi, D. L. Yandju, M. J. Boivin, G. R. Boss, Diane Stadler, William Lambert, M. R. Lasarev, L. A. Okitundu, D. Mumba Ngoyi, J. P. Banea, Daniel Tshala-Katumbay

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8 Scopus citations

Abstract

Using a matched case-control design, we sought to determine whether the odds of konzo, a distinct spastic paraparesis associated with food (cassava) cyanogenic exposure in the tropics, were associated with lower cyanide detoxification rates (CDR) and malnutrition. Children with konzo (N = 122, 5-17 years of age) were age- and sex-matched with presumably healthy controls (N = 87) and assessed for motor and cognition performances, cyanogenic exposure, nutritional status, and cyanide detoxification rates (CDR). Cyanogenic exposure was ascertained by thiocyanate (SCN) concentrations in plasma (P-SCN) and urine (U-SCN). Children with a height-for-age z-score (HAZNCHS).

Original languageEnglish (US)
JournalNeuroToxicology
DOIs
StateAccepted/In press - Dec 30 2015

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Keywords

  • Cassava
  • Cyanide detoxification
  • Konzo
  • Neurotoxicity
  • Rhodanese
  • Sulfurtransferases

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Kambale, K. J., Ali, E. R., Sadiki, N. H., Kayembe, K. P., Mvumbi, L. G., Yandju, D. L., Boivin, M. J., Boss, G. R., Stadler, D., Lambert, W., Lasarev, M. R., Okitundu, L. A., Mumba Ngoyi, D., Banea, J. P., & Tshala-Katumbay, D. (Accepted/In press). Lower sulfurtransferase detoxification rates of cyanide in konzo-A tropical spastic paralysis linked to cassava cyanogenic poisoning. NeuroToxicology. https://doi.org/10.1016/j.neuro.2016.05.016