Lower receiving frequencies than transmitting frequencies could yield improved results for contrast imaging

An in vivo study in closed chest canines

Rosemary A. Rusk, Yoshiki Mori, Xiaokui Li, Zuhua Mao, Patrick L. Von Behren, Diane Paine, Antoinette Kenny, David Sahn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Ultrasonic imaging methods of receiving at higher frequencies, which are multiples of the transmitting frequencies (harmonic imaging), are well established as a means of improving myocardial visualization in association with intravenous contrast administration. This exploratory study examined the effect of using receive frequencies that were lower than the transmit frequencies while imaging closed chest dogs with an Ensemble wideband, phase inversion contrast program on a modified Siemens Elegra scanner. Methods: Intravenous bolus injections of 0.75 mL Definity and I mL QW7437 were administered to six anesthetized dogs. Intermittent imaging for contrast visualization was performed using either a broadband array, transmitting at 1.4 MHz and receiving at 2.6-3.2 MHz or a broadband 4-7.5 MHz transducer transmitting at 6.0 MHz and receiving at 4.2-4.5 MHz. Contrast enhancement was measured by videodensitometry, sampling mid-cavity and within the myocardium before and after injection. The changes in videodensity from control to after injection were calculated for each method. Results: There was no significant difference in the change in intracavity videodensity between the two imaging strategies although there was near full intracavity saturation in all cases. However, the change in myocardial density was significantly greater for both contrast agents when using receiving frequencies lower than transmitting frequencies (P = 0.02 and 0.03). The difference in duration of the myocardial blush did not reach statistical significance but it tended to persist for longer with the lower receiving frequencies. Conclusion: Delivering sound energy at a slightly higher frequency and receiving at lower than the transmit frequency may be an advantageous method of enhancing myocardial perfusion signals during intravenous contrast echocardiography.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalEchocardiography
Volume20
Issue number3
DOIs
StatePublished - Apr 1 2003

Fingerprint

Canidae
Thorax
Dogs
Injections
Transducers
Intravenous Injections
Intravenous Administration
Contrast Media
Echocardiography
Ultrasonography
Myocardium
Perfusion

Keywords

  • Contrast
  • Echocardiography
  • Harmonics
  • Subharmonics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Lower receiving frequencies than transmitting frequencies could yield improved results for contrast imaging : An in vivo study in closed chest canines. / Rusk, Rosemary A.; Mori, Yoshiki; Li, Xiaokui; Mao, Zuhua; Von Behren, Patrick L.; Paine, Diane; Kenny, Antoinette; Sahn, David.

In: Echocardiography, Vol. 20, No. 3, 01.04.2003, p. 257-264.

Research output: Contribution to journalArticle

Rusk, Rosemary A. ; Mori, Yoshiki ; Li, Xiaokui ; Mao, Zuhua ; Von Behren, Patrick L. ; Paine, Diane ; Kenny, Antoinette ; Sahn, David. / Lower receiving frequencies than transmitting frequencies could yield improved results for contrast imaging : An in vivo study in closed chest canines. In: Echocardiography. 2003 ; Vol. 20, No. 3. pp. 257-264.
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