Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase

Hildegunn Aarsetoey, Reidun Aarsetoey, Thomas Lindner, Harry Staines, William Harris, Dennis W T Nilsen

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

In previous studies, low blood levels of n-3 fatty acids (FA) have been associated with increased risk of cardiac death, and the omega-3 index (red blood cell (RBC) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) expressed as weight percentage of total FA) has recently been proposed as a new risk factor for death from coronary artery disease, especially following sudden cardiac arrest (SCA). As blood samples often haven been harvested after the event, the aim of our study was to evaluate the stability of RBC fatty acids following SCA. The total FA profile, including the omega-3 index, was measured three times during the first 48 h in 25 survivors of out-of-hospital cardiac arrest (OHCA), in 15 patients with a myocardial infarction (MI) without SCA and in 5 healthy subjects. We could not demonstrate significant changes in the FA measurements in any of the groups, this also applied to the omega-6/omega-3 ratio and the arachidonic acid (AA)/EPA ratio. Furthermore, we compared the omega-3 index in 14 OHCA-patients suffering their first MI with that of 185 first-time MI-patients without SCA; mean values being 4.59% and 6.48%, respectively (p = 0.002). In a multivariate logistic regression analysis, a 1% increase of the omega-3 index was associated with a 58% (95% CI: 0.25-0.76%) reduction in risk of ventricular fibrillation (VF). In conclusion, the omega-3 index remained stable after an event of SCA and predicted the risk of VF.

Original languageEnglish (US)
Pages (from-to)151-161
Number of pages11
JournalLipids
Volume46
Issue number2
DOIs
StatePublished - Feb 2011
Externally publishedYes

Fingerprint

Sudden Cardiac Death
Survivors
Blood
Fatty Acids
Eicosapentaenoic Acid
Out-of-Hospital Cardiac Arrest
Myocardial Infarction
Ventricular Fibrillation
Erythrocytes
Docosahexaenoic Acids
Omega-3 Fatty Acids
Arachidonic Acid
Regression analysis
Logistics
Risk Reduction Behavior
Cells
Coronary Artery Disease
Healthy Volunteers
Logistic Models
Regression Analysis

Keywords

  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Fatty acid stability
  • Myocardial infarction
  • n-3 fatty acids
  • Red blood cell membranes
  • Sudden cardiac arrest
  • The omega-3 index
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Organic Chemistry

Cite this

Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. / Aarsetoey, Hildegunn; Aarsetoey, Reidun; Lindner, Thomas; Staines, Harry; Harris, William; Nilsen, Dennis W T.

In: Lipids, Vol. 46, No. 2, 02.2011, p. 151-161.

Research output: Contribution to journalArticle

Aarsetoey, H, Aarsetoey, R, Lindner, T, Staines, H, Harris, W & Nilsen, DWT 2011, 'Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase', Lipids, vol. 46, no. 2, pp. 151-161. https://doi.org/10.1007/s11745-010-3511-3
Aarsetoey, Hildegunn ; Aarsetoey, Reidun ; Lindner, Thomas ; Staines, Harry ; Harris, William ; Nilsen, Dennis W T. / Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. In: Lipids. 2011 ; Vol. 46, No. 2. pp. 151-161.
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AU - Harris, William

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