Low-Grade Appendiceal Mucinous Neoplasms: A Single Institution Experience of 64 Cases With Clinical Follow-up and Correlation With the Current (Eighth Edition) AJCC Staging

Mary Wong, Brad Barrows, Alexandra Gangi, Stacey Kim, Richard B. Mertens, Deepti Dhall

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background. In this single-institution study, we applied the current (eighth edition) American Joint Committee on Cancer pathologic staging criteria to 64 low-grade mucinous neoplasms of the appendix (LAMNs), examined their histopathologic features, and studied the patients’ clinical outcomes. Design. Sixty-four LAMNs, with a median follow-up of 52 months, were reviewed. Results. The distribution of pathologic stages was pTis (n = 39), pT3 (n = 1), pT4a (n = 5), pT4aM1a (n = 8), and pT4aM1b (n = 11). Recurrence was observed in only 2 patients (both with pT4aM1b disease), one of whom died of disease. All remaining patients were disease-free after a median clinical follow-up of 60 months. Conclusions. Our study confirms that pTis LAMNs have an excellent prognosis and suggests that pT4a and pT4aM1a LAMNs may also have a low risk of developing progressive disease.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalInternational Journal of Surgical Pathology
Volume28
Issue number3
DOIs
StatePublished - May 1 2020
Externally publishedYes

Keywords

  • AJCC staging
  • appendix
  • LAMN
  • low-grade appendiceal mucinous neoplasm
  • TNM staging

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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