Low-Dose Bromocriptine Therapy in Parkinson's Disease

Ronald F. Pfeiffer, Kathleen Wilken, Carolyn Glaeske, Agapito S. Lorenzo

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3 Scopus citations

Abstract

The efficacy of low-dose bromocriptine mesylate administration (20 mg daily or less) was evaluated in a double-blind study. Nine of 16 individuals receiving bromocriptine completed the 40-week study. Modest, but significant, improvement was derived from bromocriptine therapy. Improvement was most evident in tremor. Maximum improvement was achieved with doses between 7.5 and 15.0 mg daily, with some decline in efficacy as doses approached 20 mg. Adverse effects were common, but were generally mild in severity. Our results suggest that bromocriptine in low doses may be an effective adjunct to carbidopa and levodopa (Sinemet) in the treatment of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)586-588
Number of pages3
JournalArchives of Neurology
Volume42
Issue number6
DOIs
StatePublished - Jun 1985

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ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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