Low-dose aspirin reduces uteroplacental vascular impedance in early and mid gestation in IVF and ICSI patients

A randomized, placebo-controlled double-blind study

M. Haapsamo, H. Martikainen, Juha Rasanen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To determine whether low-dose aspirin improves uteroplacental hemodynamics in unselected in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) subjects when medication is started concomitantly with controlled ovarian hyperstimulation. Methods: Thirty-seven pregnant women who had undergone IVF/ICSI and had been randomized to receive 100 mg aspirin (n = 17) or placebo (n = 20) daily, started concomitantly with controlled ovarian hyperstimulation, were included in this study. Doppler ultrasound examination was performed at 6, 10, 13 and 18 weeks' gestation. Uterine artery (UtA) pulsatility index (PI) was calculated and bilateral UtA notching was noted. Subplacental arcuate artery PI was obtained at 6 and 10 weeks' gestation. Umbilical artery (UA) PI and mean velocity were calculated at 10, 13 and 18 weeks' gestation. In the aspirin group there was one early pregnancy miscarriage, and one patient discontinued the study medication owing to early pregnancy bleeding. A total of 15 women in the aspirin group and 20 women in the placebo group underwent the complete ultrasound protocol. Results: At 6 weeks' gestation, arcuate artery PI and at 18 weeks' gestation, UtA PI were lower (P <0.05) in the aspirin group than in the placebo group. At 18 weeks' gestation, bilateral UtA notching tended to be more common in the placebo group (40%) than in the aspirin group (13%) (P = 0.06). UA PI and mean velocity did not differ significantly between the groups. Conclusion: Low-dose aspirin reduces uteroplacental vascular impedance in early and mid pregnancy in unselected IVF/ICSI subjects when medication is started concomitantly with controlled ovarian hyperstimulation.

Original languageEnglish (US)
Pages (from-to)687-693
Number of pages7
JournalUltrasound in Obstetrics and Gynecology
Volume32
Issue number5
DOIs
StatePublished - Oct 2008

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Intracytoplasmic Sperm Injections
Electric Impedance
Double-Blind Method
Aspirin
Blood Vessels
Placebos
Pregnancy
Uterine Artery
Fertilization in Vitro
Umbilical Arteries
Arteries
Doppler Ultrasonography
Spontaneous Abortion
Pregnant Women
Hemodynamics
Hemorrhage

Keywords

  • Assisted reproduction
  • Doppler ultrasonography
  • Placenta
  • Uteroplacental hemodynamics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine

Cite this

Low-dose aspirin reduces uteroplacental vascular impedance in early and mid gestation in IVF and ICSI patients : A randomized, placebo-controlled double-blind study. / Haapsamo, M.; Martikainen, H.; Rasanen, Juha.

In: Ultrasound in Obstetrics and Gynecology, Vol. 32, No. 5, 10.2008, p. 687-693.

Research output: Contribution to journalArticle

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abstract = "Objective: To determine whether low-dose aspirin improves uteroplacental hemodynamics in unselected in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) subjects when medication is started concomitantly with controlled ovarian hyperstimulation. Methods: Thirty-seven pregnant women who had undergone IVF/ICSI and had been randomized to receive 100 mg aspirin (n = 17) or placebo (n = 20) daily, started concomitantly with controlled ovarian hyperstimulation, were included in this study. Doppler ultrasound examination was performed at 6, 10, 13 and 18 weeks' gestation. Uterine artery (UtA) pulsatility index (PI) was calculated and bilateral UtA notching was noted. Subplacental arcuate artery PI was obtained at 6 and 10 weeks' gestation. Umbilical artery (UA) PI and mean velocity were calculated at 10, 13 and 18 weeks' gestation. In the aspirin group there was one early pregnancy miscarriage, and one patient discontinued the study medication owing to early pregnancy bleeding. A total of 15 women in the aspirin group and 20 women in the placebo group underwent the complete ultrasound protocol. Results: At 6 weeks' gestation, arcuate artery PI and at 18 weeks' gestation, UtA PI were lower (P <0.05) in the aspirin group than in the placebo group. At 18 weeks' gestation, bilateral UtA notching tended to be more common in the placebo group (40{\%}) than in the aspirin group (13{\%}) (P = 0.06). UA PI and mean velocity did not differ significantly between the groups. Conclusion: Low-dose aspirin reduces uteroplacental vascular impedance in early and mid pregnancy in unselected IVF/ICSI subjects when medication is started concomitantly with controlled ovarian hyperstimulation.",
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