Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans

Andrew A. Butler, Charmaine S. Tam, Kimber L. Stanhope, Bruce Wolfe, Mohamed R. Ali, Majella O'Keeffe, Marie Pierre St-Onge, Eric Ravussin, Peter J. Havel

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Context: Mouse studies suggest that adropin, a peptide hormone, is required for metabolic homeostasis and prevention of obesity-associated insulin resistance. Whether obesity and insulin resistance are associated with low plasma adropin levels in humans is not known. Objectives: Our objective was to investigate the hypothesis that obesity and indicators of insulin resistance are associated with low adropin levels and determine whether weight loss regulates adropin levels. Design and Participants: Plasma was obtained from 85 female [age 21-67 yr, body mass index (BMI) 19.4-71.5 kg/m2] and 45 male (age 18-70 yr, BMI 19.1-62.6 kg/m2) volunteers for other clinical studies. The impact of Roux-en-Y gastric bypass was investigated in 19 obese females (BMI 37-65 kg/m2) using samples collected at baseline and 1-12 months after surgery. Results: Adropin levels correlate negatively with BMI (r = -0.335, P <0.001) and age (r = -0.263, P = 0.003). Age-adjusted adropin levels are higher in males [4.1 ng/ml; 95% confidence interval (CI) = 3.6-4.6 ng/ml] than females (3.0 ng/ml; 95% CI = 2.6 -3.4 ng/ml) (P = 0.001). In all subjects, lower age-adjusted adropin levels were observed in overweight (3.3 ng/ml; 95% CI = 2.8 -3.8 ng/ml, P = 0.033) and obese (2.7 ng/ml; 95% CI = 2.1-3.3 ng/ml, P = 0.001) compared with healthy-weight subjects (4.1 ng/ml; 95% CI = 3.6-4.5 ng/ml). This effect was gender specific (weight category x gender, P <0.001) and was observed in males only. Aging and diagnosis with two or more metabolic syndrome risk factors was associated with low adropin levels, irrespective of sex. Adropin concentrations increased after Roux-en-Y gastric bypass, peaking 3 months after surgery (P <0.01). Conclusions: Although males exhibit higher adropin levels that are reduced by obesity, aging and markers of insulin resistance are associated with low plasma adropin irrespective of sex.

Original languageEnglish (US)
Pages (from-to)3783-3791
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number10
DOIs
StatePublished - Oct 2012

Fingerprint

Gastric Bypass
Metabolic Diseases
Surgery
Obesity
Aging of materials
Confidence Intervals
Insulin Resistance
Insulin
Body Mass Index
Plasmas
Peptide Hormones
Weights and Measures
Density (specific gravity)
Weight Loss
Volunteers
Healthy Volunteers
Homeostasis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. / Butler, Andrew A.; Tam, Charmaine S.; Stanhope, Kimber L.; Wolfe, Bruce; Ali, Mohamed R.; O'Keeffe, Majella; St-Onge, Marie Pierre; Ravussin, Eric; Havel, Peter J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 10, 10.2012, p. 3783-3791.

Research output: Contribution to journalArticle

Butler, Andrew A. ; Tam, Charmaine S. ; Stanhope, Kimber L. ; Wolfe, Bruce ; Ali, Mohamed R. ; O'Keeffe, Majella ; St-Onge, Marie Pierre ; Ravussin, Eric ; Havel, Peter J. / Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. In: Journal of Clinical Endocrinology and Metabolism. 2012 ; Vol. 97, No. 10. pp. 3783-3791.
@article{983babbd780240ee8edc46fae988c5be,
title = "Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans",
abstract = "Context: Mouse studies suggest that adropin, a peptide hormone, is required for metabolic homeostasis and prevention of obesity-associated insulin resistance. Whether obesity and insulin resistance are associated with low plasma adropin levels in humans is not known. Objectives: Our objective was to investigate the hypothesis that obesity and indicators of insulin resistance are associated with low adropin levels and determine whether weight loss regulates adropin levels. Design and Participants: Plasma was obtained from 85 female [age 21-67 yr, body mass index (BMI) 19.4-71.5 kg/m2] and 45 male (age 18-70 yr, BMI 19.1-62.6 kg/m2) volunteers for other clinical studies. The impact of Roux-en-Y gastric bypass was investigated in 19 obese females (BMI 37-65 kg/m2) using samples collected at baseline and 1-12 months after surgery. Results: Adropin levels correlate negatively with BMI (r = -0.335, P <0.001) and age (r = -0.263, P = 0.003). Age-adjusted adropin levels are higher in males [4.1 ng/ml; 95{\%} confidence interval (CI) = 3.6-4.6 ng/ml] than females (3.0 ng/ml; 95{\%} CI = 2.6 -3.4 ng/ml) (P = 0.001). In all subjects, lower age-adjusted adropin levels were observed in overweight (3.3 ng/ml; 95{\%} CI = 2.8 -3.8 ng/ml, P = 0.033) and obese (2.7 ng/ml; 95{\%} CI = 2.1-3.3 ng/ml, P = 0.001) compared with healthy-weight subjects (4.1 ng/ml; 95{\%} CI = 3.6-4.5 ng/ml). This effect was gender specific (weight category x gender, P <0.001) and was observed in males only. Aging and diagnosis with two or more metabolic syndrome risk factors was associated with low adropin levels, irrespective of sex. Adropin concentrations increased after Roux-en-Y gastric bypass, peaking 3 months after surgery (P <0.01). Conclusions: Although males exhibit higher adropin levels that are reduced by obesity, aging and markers of insulin resistance are associated with low plasma adropin irrespective of sex.",
author = "Butler, {Andrew A.} and Tam, {Charmaine S.} and Stanhope, {Kimber L.} and Bruce Wolfe and Ali, {Mohamed R.} and Majella O'Keeffe and St-Onge, {Marie Pierre} and Eric Ravussin and Havel, {Peter J.}",
year = "2012",
month = "10",
doi = "10.1210/jc.2012-2194",
language = "English (US)",
volume = "97",
pages = "3783--3791",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "10",

}

TY - JOUR

T1 - Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans

AU - Butler, Andrew A.

AU - Tam, Charmaine S.

AU - Stanhope, Kimber L.

AU - Wolfe, Bruce

AU - Ali, Mohamed R.

AU - O'Keeffe, Majella

AU - St-Onge, Marie Pierre

AU - Ravussin, Eric

AU - Havel, Peter J.

PY - 2012/10

Y1 - 2012/10

N2 - Context: Mouse studies suggest that adropin, a peptide hormone, is required for metabolic homeostasis and prevention of obesity-associated insulin resistance. Whether obesity and insulin resistance are associated with low plasma adropin levels in humans is not known. Objectives: Our objective was to investigate the hypothesis that obesity and indicators of insulin resistance are associated with low adropin levels and determine whether weight loss regulates adropin levels. Design and Participants: Plasma was obtained from 85 female [age 21-67 yr, body mass index (BMI) 19.4-71.5 kg/m2] and 45 male (age 18-70 yr, BMI 19.1-62.6 kg/m2) volunteers for other clinical studies. The impact of Roux-en-Y gastric bypass was investigated in 19 obese females (BMI 37-65 kg/m2) using samples collected at baseline and 1-12 months after surgery. Results: Adropin levels correlate negatively with BMI (r = -0.335, P <0.001) and age (r = -0.263, P = 0.003). Age-adjusted adropin levels are higher in males [4.1 ng/ml; 95% confidence interval (CI) = 3.6-4.6 ng/ml] than females (3.0 ng/ml; 95% CI = 2.6 -3.4 ng/ml) (P = 0.001). In all subjects, lower age-adjusted adropin levels were observed in overweight (3.3 ng/ml; 95% CI = 2.8 -3.8 ng/ml, P = 0.033) and obese (2.7 ng/ml; 95% CI = 2.1-3.3 ng/ml, P = 0.001) compared with healthy-weight subjects (4.1 ng/ml; 95% CI = 3.6-4.5 ng/ml). This effect was gender specific (weight category x gender, P <0.001) and was observed in males only. Aging and diagnosis with two or more metabolic syndrome risk factors was associated with low adropin levels, irrespective of sex. Adropin concentrations increased after Roux-en-Y gastric bypass, peaking 3 months after surgery (P <0.01). Conclusions: Although males exhibit higher adropin levels that are reduced by obesity, aging and markers of insulin resistance are associated with low plasma adropin irrespective of sex.

AB - Context: Mouse studies suggest that adropin, a peptide hormone, is required for metabolic homeostasis and prevention of obesity-associated insulin resistance. Whether obesity and insulin resistance are associated with low plasma adropin levels in humans is not known. Objectives: Our objective was to investigate the hypothesis that obesity and indicators of insulin resistance are associated with low adropin levels and determine whether weight loss regulates adropin levels. Design and Participants: Plasma was obtained from 85 female [age 21-67 yr, body mass index (BMI) 19.4-71.5 kg/m2] and 45 male (age 18-70 yr, BMI 19.1-62.6 kg/m2) volunteers for other clinical studies. The impact of Roux-en-Y gastric bypass was investigated in 19 obese females (BMI 37-65 kg/m2) using samples collected at baseline and 1-12 months after surgery. Results: Adropin levels correlate negatively with BMI (r = -0.335, P <0.001) and age (r = -0.263, P = 0.003). Age-adjusted adropin levels are higher in males [4.1 ng/ml; 95% confidence interval (CI) = 3.6-4.6 ng/ml] than females (3.0 ng/ml; 95% CI = 2.6 -3.4 ng/ml) (P = 0.001). In all subjects, lower age-adjusted adropin levels were observed in overweight (3.3 ng/ml; 95% CI = 2.8 -3.8 ng/ml, P = 0.033) and obese (2.7 ng/ml; 95% CI = 2.1-3.3 ng/ml, P = 0.001) compared with healthy-weight subjects (4.1 ng/ml; 95% CI = 3.6-4.5 ng/ml). This effect was gender specific (weight category x gender, P <0.001) and was observed in males only. Aging and diagnosis with two or more metabolic syndrome risk factors was associated with low adropin levels, irrespective of sex. Adropin concentrations increased after Roux-en-Y gastric bypass, peaking 3 months after surgery (P <0.01). Conclusions: Although males exhibit higher adropin levels that are reduced by obesity, aging and markers of insulin resistance are associated with low plasma adropin irrespective of sex.

UR - http://www.scopus.com/inward/record.url?scp=84867256162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867256162&partnerID=8YFLogxK

U2 - 10.1210/jc.2012-2194

DO - 10.1210/jc.2012-2194

M3 - Article

C2 - 22872690

AN - SCOPUS:84867256162

VL - 97

SP - 3783

EP - 3791

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 10

ER -