TY - JOUR
T1 - Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice
AU - Soderling, Scott H.
AU - Langeberg, Lorene K.
AU - Soderling, Jacquelyn A.
AU - Davee, Stephen M.
AU - Simerly, Richard
AU - Raber, Jacob
AU - Scott, John D.
PY - 2003/2/18
Y1 - 2003/2/18
N2 - The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.
AB - The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.
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U2 - 10.1073/pnas.0438033100
DO - 10.1073/pnas.0438033100
M3 - Article
C2 - 12578964
AN - SCOPUS:0037452615
SN - 0027-8424
VL - 100
SP - 1723
EP - 1728
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 4
ER -