Loss of HLA class-I alleles, heavy chains and β2-microglobulin in colorectal cancer

L. Kalkamanis, K. C. Gatter, Ann Hill, N. Mortensen, A. L. Harris, P. Krausa, A. McMichael, J. G. Bodmer, W. F. Bodmer

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Using immunohistochemical methods, we have analysed colorectal biopsies of normal mucosa, metaplastic polyps (5 cases), adenomas (15 cases) and adenocarcinomas (70 cases) with 13 monoclonal antibodies (MAbs) to allelic products of the HLA-A, B, C loci. Nine of the 70 carcinomas showed total loss of HLA Class-I molecules due to an underlying defect regarding not only the expression of β2-microglobulin (β2-m), but also the heavy chains of HLA A, B and C loci, or both. Much commoner was a loss of one or more Class-I alleles as follows: A1/Aw36 (completely lost in 4 of 29 cases and focally lost in another 2), A2 (in 1 of 37 cases), A3 (in 2 of 14 cases), A11/28/31/33 (in 3 of 11 cases), B7 (in 3 of 13 and focally in 1 other case), B17 (in 1 case), Bw4 (in 3 of 45 and focally in another 6), Bw6 (in 9 of 62 and focally in another 3). Focal selective loss (Bw6 and a combined A1-Bw6), was observed in 2 adenomas. Normal colonic mucosa, as well as stromal and lymphoid cells present between the neoplastic glands, were studied in each case as a control. A particular allele was only considered to be lost by the malignant cells if it was still expressed on these adjacent tissues.

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalInternational Journal of Cancer
Volume51
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

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HLA-A Antigens
HLA-B Antigens
Adenoma
Colorectal Neoplasms
Mucous Membrane
Alleles
HLA-C Antigens
Stromal Cells
Polyps
varespladib methyl
Adenocarcinoma
Monoclonal Antibodies
Lymphocytes
Carcinoma
Biopsy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kalkamanis, L., Gatter, K. C., Hill, A., Mortensen, N., Harris, A. L., Krausa, P., ... Bodmer, W. F. (1992). Loss of HLA class-I alleles, heavy chains and β2-microglobulin in colorectal cancer. International Journal of Cancer, 51(3), 379-385. https://doi.org/10.1002/ijc.2910510308

Loss of HLA class-I alleles, heavy chains and β2-microglobulin in colorectal cancer. / Kalkamanis, L.; Gatter, K. C.; Hill, Ann; Mortensen, N.; Harris, A. L.; Krausa, P.; McMichael, A.; Bodmer, J. G.; Bodmer, W. F.

In: International Journal of Cancer, Vol. 51, No. 3, 1992, p. 379-385.

Research output: Contribution to journalArticle

Kalkamanis, L, Gatter, KC, Hill, A, Mortensen, N, Harris, AL, Krausa, P, McMichael, A, Bodmer, JG & Bodmer, WF 1992, 'Loss of HLA class-I alleles, heavy chains and β2-microglobulin in colorectal cancer', International Journal of Cancer, vol. 51, no. 3, pp. 379-385. https://doi.org/10.1002/ijc.2910510308
Kalkamanis, L. ; Gatter, K. C. ; Hill, Ann ; Mortensen, N. ; Harris, A. L. ; Krausa, P. ; McMichael, A. ; Bodmer, J. G. ; Bodmer, W. F. / Loss of HLA class-I alleles, heavy chains and β2-microglobulin in colorectal cancer. In: International Journal of Cancer. 1992 ; Vol. 51, No. 3. pp. 379-385.
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