Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme

Masahito Fujimoto, Daniel W. Fults, Gregory A. Thomas, Yusuke Nakamura, M. Peter Heilbrun, Ray White, Jim L. Story, Susan L. Naylor, Kathleen S. Kagan-Hallet, Peter J. Sheridan

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

Recessive mutations, revealed by loss of the wild-type allele, have been associated with the development of a variety of cancers in children and adults. Polymorphic chromosome 10 markers were used to screen paired tumor and lymphocyte DNA samples in 13 patients with glioblastoma multiforme. Ten patients showed loss of constitutional heterozygosity in the tumor samples. This finding suggests that a recessive gene involved in the development of glioblastoma multiforme is present on chromosome 10.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalGenomics
Volume4
Issue number2
DOIs
StatePublished - Feb 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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