Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence

N. D. Volkow, L. Chang, G. J. Wang, J. S. Fowler, D. Franceschi, M. Sedler, S. J. Gatley, E. Miller, Robert Hitzemann, Y. S. Ding, J. Logan

Research output: Contribution to journalArticle

443 Citations (Scopus)

Abstract

Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant loss of DA transporters (used as markers of the DA terminal) that are associated with slower motor function and decreased memory. The extent to which the loss of DA transporters predisposes methamphetamine abusers to neurodegenerative disorders such as Parkinsonism is unclear and may depend in part on the degree of recovery. Here we assessed the effects of protracted abstinence on the loss of DA transporters in striatum, in methamphetamine abusers using positron emission tomography and [11C]d-threo-methylphenidate (DA transporter radioligand). Brain DA transporters in five methamphetamine abusers evaluated during short abstinence (

Original languageEnglish (US)
Pages (from-to)9414-9418
Number of pages5
JournalJournal of Neuroscience
Volume21
Issue number23
StatePublished - Dec 1 2001
Externally publishedYes

Fingerprint

Dopamine Plasma Membrane Transport Proteins
Methamphetamine
Dopamine
Methylphenidate
Laboratory Animals
Parkinsonian Disorders
Street Drugs
Neurodegenerative Diseases
Positron-Emission Tomography
Brain

Keywords

  • Addiction
  • Detoxification
  • Dopamine terminal
  • Dopamine transporters
  • Imaging
  • Methamphetamine
  • Neurotoxicity
  • Positron emission tomography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Volkow, N. D., Chang, L., Wang, G. J., Fowler, J. S., Franceschi, D., Sedler, M., ... Logan, J. (2001). Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. Journal of Neuroscience, 21(23), 9414-9418.

Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. / Volkow, N. D.; Chang, L.; Wang, G. J.; Fowler, J. S.; Franceschi, D.; Sedler, M.; Gatley, S. J.; Miller, E.; Hitzemann, Robert; Ding, Y. S.; Logan, J.

In: Journal of Neuroscience, Vol. 21, No. 23, 01.12.2001, p. 9414-9418.

Research output: Contribution to journalArticle

Volkow, ND, Chang, L, Wang, GJ, Fowler, JS, Franceschi, D, Sedler, M, Gatley, SJ, Miller, E, Hitzemann, R, Ding, YS & Logan, J 2001, 'Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence' Journal of Neuroscience, vol. 21, no. 23, pp. 9414-9418.
Volkow ND, Chang L, Wang GJ, Fowler JS, Franceschi D, Sedler M et al. Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. Journal of Neuroscience. 2001 Dec 1;21(23):9414-9418.
Volkow, N. D. ; Chang, L. ; Wang, G. J. ; Fowler, J. S. ; Franceschi, D. ; Sedler, M. ; Gatley, S. J. ; Miller, E. ; Hitzemann, Robert ; Ding, Y. S. ; Logan, J. / Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. In: Journal of Neuroscience. 2001 ; Vol. 21, No. 23. pp. 9414-9418.
@article{d409cc1ab5f0473a8d3a55a5d3872554,
title = "Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence",
abstract = "Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant loss of DA transporters (used as markers of the DA terminal) that are associated with slower motor function and decreased memory. The extent to which the loss of DA transporters predisposes methamphetamine abusers to neurodegenerative disorders such as Parkinsonism is unclear and may depend in part on the degree of recovery. Here we assessed the effects of protracted abstinence on the loss of DA transporters in striatum, in methamphetamine abusers using positron emission tomography and [11C]d-threo-methylphenidate (DA transporter radioligand). Brain DA transporters in five methamphetamine abusers evaluated during short abstinence (",
keywords = "Addiction, Detoxification, Dopamine terminal, Dopamine transporters, Imaging, Methamphetamine, Neurotoxicity, Positron emission tomography",
author = "Volkow, {N. D.} and L. Chang and Wang, {G. J.} and Fowler, {J. S.} and D. Franceschi and M. Sedler and Gatley, {S. J.} and E. Miller and Robert Hitzemann and Ding, {Y. S.} and J. Logan",
year = "2001",
month = "12",
day = "1",
language = "English (US)",
volume = "21",
pages = "9414--9418",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "23",

}

TY - JOUR

T1 - Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence

AU - Volkow, N. D.

AU - Chang, L.

AU - Wang, G. J.

AU - Fowler, J. S.

AU - Franceschi, D.

AU - Sedler, M.

AU - Gatley, S. J.

AU - Miller, E.

AU - Hitzemann, Robert

AU - Ding, Y. S.

AU - Logan, J.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant loss of DA transporters (used as markers of the DA terminal) that are associated with slower motor function and decreased memory. The extent to which the loss of DA transporters predisposes methamphetamine abusers to neurodegenerative disorders such as Parkinsonism is unclear and may depend in part on the degree of recovery. Here we assessed the effects of protracted abstinence on the loss of DA transporters in striatum, in methamphetamine abusers using positron emission tomography and [11C]d-threo-methylphenidate (DA transporter radioligand). Brain DA transporters in five methamphetamine abusers evaluated during short abstinence (

AB - Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant loss of DA transporters (used as markers of the DA terminal) that are associated with slower motor function and decreased memory. The extent to which the loss of DA transporters predisposes methamphetamine abusers to neurodegenerative disorders such as Parkinsonism is unclear and may depend in part on the degree of recovery. Here we assessed the effects of protracted abstinence on the loss of DA transporters in striatum, in methamphetamine abusers using positron emission tomography and [11C]d-threo-methylphenidate (DA transporter radioligand). Brain DA transporters in five methamphetamine abusers evaluated during short abstinence (

KW - Addiction

KW - Detoxification

KW - Dopamine terminal

KW - Dopamine transporters

KW - Imaging

KW - Methamphetamine

KW - Neurotoxicity

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0035576119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035576119&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 9414

EP - 9418

JO - Journal of Neuroscience

T2 - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 23

ER -