Loss of alveolar bone due to periodontal disease exhibits a threshold on the association with coronary heart disease

Amy C. Alman, Lonnie R. Johnson, David Calverley, Gary K. Grunwald, Dennis C. Lezotte, Jeri E F Harwood, John E. Hokanson

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Background: A number of epidemiologic studies were published that looked at the association between coronary heart disease (CHD) and periodontal disease. However, debate exists about whether this association is a true relationship or simply an example of an uncontrolled confounder. This retrospective cohort study examines the relationship between periodontal disease and CHD. Methods: Digital panoramic radiographs were used to assess alveolar bone loss (ABL) using a Schei ruler. Participants consisted of Veterans Administration (VA) patients who were eligible for dental benefits and had a digital panoramic radiograph taken at the VA Medical Center, Denver, Colorado. Information on CHD and other important clinical variables were obtained from electronic medical records. Results: The examination of the relationship between ABL and CHD revealed a significant non-linear relationship with a threshold at ̃20% bone loss with a doubling of the probability ratios of CHD compared to those at 7.5% bone loss. Conclusions: To our knowledge, this is the first study to demonstrate a non-linear relationship between ABL and CHD. A significant positive association between ABL and CHD was found at even low levels of bone loss between 10% and 20%. J Periodontol 2011;82:1304-1313.

    Original languageEnglish (US)
    Pages (from-to)1304-1313
    Number of pages10
    JournalJournal of Periodontology
    Volume82
    Issue number9
    DOIs
    StatePublished - Sep 2011

    Fingerprint

    Alveolar Bone Loss
    Periodontal Diseases
    Coronary Disease
    United States Department of Veterans Affairs
    Bone and Bones
    Electronic Health Records
    Epidemiologic Studies
    Tooth
    Cohort Studies
    Retrospective Studies

    Keywords

    • Alveolar bone loss
    • Atherosclerosis
    • Coronary disease
    • Inflammation
    • Periodontitis

    ASJC Scopus subject areas

    • Periodontics

    Cite this

    Alman, A. C., Johnson, L. R., Calverley, D., Grunwald, G. K., Lezotte, D. C., Harwood, J. E. F., & Hokanson, J. E. (2011). Loss of alveolar bone due to periodontal disease exhibits a threshold on the association with coronary heart disease. Journal of Periodontology, 82(9), 1304-1313. https://doi.org/10.1902/jop.2011.100647

    Loss of alveolar bone due to periodontal disease exhibits a threshold on the association with coronary heart disease. / Alman, Amy C.; Johnson, Lonnie R.; Calverley, David; Grunwald, Gary K.; Lezotte, Dennis C.; Harwood, Jeri E F; Hokanson, John E.

    In: Journal of Periodontology, Vol. 82, No. 9, 09.2011, p. 1304-1313.

    Research output: Contribution to journalArticle

    Alman, AC, Johnson, LR, Calverley, D, Grunwald, GK, Lezotte, DC, Harwood, JEF & Hokanson, JE 2011, 'Loss of alveolar bone due to periodontal disease exhibits a threshold on the association with coronary heart disease', Journal of Periodontology, vol. 82, no. 9, pp. 1304-1313. https://doi.org/10.1902/jop.2011.100647
    Alman, Amy C. ; Johnson, Lonnie R. ; Calverley, David ; Grunwald, Gary K. ; Lezotte, Dennis C. ; Harwood, Jeri E F ; Hokanson, John E. / Loss of alveolar bone due to periodontal disease exhibits a threshold on the association with coronary heart disease. In: Journal of Periodontology. 2011 ; Vol. 82, No. 9. pp. 1304-1313.
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