Loss of adhesion. A novel and distinct effect of the cytotoxic T lymphocyte-target interaction

J. H. Russell, L. Musil, D. E. McCulley

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The ability of adherent target cells to remain attached to their substratum is lost as an early consequence of interaction with cytotoxic T lymphocytes. This phenomenon is shown to be a distinct event in the lytic process induced by cytotoxic T lymphocytes and does not occur during lysis by antibody plus complement. Thus loss of adhesion represent a previously unrecognized form of immune damage which may have important implications in both normal and pathologic responses.

Original languageEnglish (US)
Pages (from-to)427-432
Number of pages6
JournalJournal of Immunology
Volume140
Issue number2
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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