Longterm survival of lupus nephritis patients treated with azathioprine and prednisone

E. V. Barnett, L. Dornfeld, D. B.N. Lee, M. R. Liebling

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

47 SLE patients with severe renal disease characterized by renal biopsy documentation of diffuse proliferative or membranous glomerulonephritis or the nephrotic syndrome have been treated with azathioprine and prednisone in combination and followed for up to 12 years. Survivorship was 82% ± 6% for five years and 74% ± 8% for 10 years. There have been eight deaths and two patients have gone on hemodialysis. Five of the eight deaths are attributable to superinfection. Improvement in creatinine clearance was documented in 21 and decreased proteinuria in 35 of the patients. A therapeutic program, which included high dose corticosteroids initially, the combinations of azathioprine with corticosteroids chronically, and the rapid reduction in corticosteroid dosage to an alternate day schedule, appears to contribute to improved survivorship.

Original languageEnglish (US)
Pages (from-to)275-287
Number of pages13
JournalJournal of Rheumatology
Volume5
Issue number3
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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