Longitudinal MR spectroscopic imaging of pediatric diffuse pontine tumors to assess tumor aggression and progression

S. B. Thakur, S. Karimi, I. J. Dunkel, J. A. Koutcher, Wei Huang

Research output: Contribution to journalArticle

27 Scopus citations


Two pediatric patients with diffuse pontine tumors underwent MR spectroscopic imaging pre- and postradiation. Choline/creatine (Cho/Cr) and Cho/N-acetylaspartate (NAA) ratios were elevated before treatment, with no MR imaging contrast enhancement. These ratios were further elevated at 2 posttreatment follow-up studies, despite signs of excellent clinical improvement at initial follow-up. This study suggests that MR spectroscopic imaging is more specific in assessing the aggressiveness of diffuse pontine tumors than conventional MR imaging and can serve as a valuable tool in early prognostication.

Original languageEnglish (US)
Pages (from-to)806-809
Number of pages4
JournalAmerican Journal of Neuroradiology
Issue number4
StatePublished - Apr 1 2006


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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