Longitudinal assessment of chlorpyrifos exposure and self-reported neurological symptoms in adolescent pesticide applicators

Khalid Khan, Ahmed A. Ismail, Gaafar Abdel Rasoul, Matthew R. Bonner, Michael R. Lasarev, Olfat Hendy, Manal Al-Batanony, Alice L. Crane, Steven T. Singleton, James R. Olson, Diane Rohlman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objectives: Occupational exposure of organophosphorus pesticides, such as chlorpyrifos (CPF), in adolescents is of particular concern because of the potential vulnerability of the developing neurological system. The objectives of this study were to examine how neurological symptoms reported over the application season vary across time, whether these effects are reversible postapplication and if there are associations between CPF biomarkers and neurological symptoms in an adolescent study population. Setting: The longitudinal study was conducted in two agricultural districts of Menoufia Governorate, Egypt between April 2010 and January 2011. Participants: Male adolescent participants, including CPF applicators (n=57) and non-applicators (n=38), were recruited. Primary and secondary outcome measures: Self-reported data for 25 neurological symptoms were collected at 32 time points over the 8-month period before, during and after the application season. Additionally, urine and blood samples were collected to measure urine trichloro-2-pyridinol (TCPy), a CPF-specific biomarker and blood cholinesterase activity. Results: Applicators and non-applicators report the highest numbers of symptoms during the application season, followed by a reduction in symptoms after the application ended. Applicators reported a greater percentage of neurological symptoms, relative to baseline, than non-applicators after accounting for potential covariates. Among the applicators, cumulative TCPy was positively and significantly associated with the average percentage of symptoms (B=4.56, 95% CI 3.29 to 5.84; p

Original languageEnglish (US)
Article numbere004177
JournalBMJ Open
Volume4
Issue number3
DOIs
StatePublished - 2014

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Chlorpyrifos
Pesticides
Biomarkers
Urine
Egypt
Cholinesterases
Occupational Exposure
Longitudinal Studies
Outcome Assessment (Health Care)
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Khan, K., Ismail, A. A., Abdel Rasoul, G., Bonner, M. R., Lasarev, M. R., Hendy, O., ... Rohlman, D. (2014). Longitudinal assessment of chlorpyrifos exposure and self-reported neurological symptoms in adolescent pesticide applicators. BMJ Open, 4(3), [e004177]. https://doi.org/10.1136/bmjopen-2013-004177

Longitudinal assessment of chlorpyrifos exposure and self-reported neurological symptoms in adolescent pesticide applicators. / Khan, Khalid; Ismail, Ahmed A.; Abdel Rasoul, Gaafar; Bonner, Matthew R.; Lasarev, Michael R.; Hendy, Olfat; Al-Batanony, Manal; Crane, Alice L.; Singleton, Steven T.; Olson, James R.; Rohlman, Diane.

In: BMJ Open, Vol. 4, No. 3, e004177, 2014.

Research output: Contribution to journalArticle

Khan, K, Ismail, AA, Abdel Rasoul, G, Bonner, MR, Lasarev, MR, Hendy, O, Al-Batanony, M, Crane, AL, Singleton, ST, Olson, JR & Rohlman, D 2014, 'Longitudinal assessment of chlorpyrifos exposure and self-reported neurological symptoms in adolescent pesticide applicators', BMJ Open, vol. 4, no. 3, e004177. https://doi.org/10.1136/bmjopen-2013-004177
Khan, Khalid ; Ismail, Ahmed A. ; Abdel Rasoul, Gaafar ; Bonner, Matthew R. ; Lasarev, Michael R. ; Hendy, Olfat ; Al-Batanony, Manal ; Crane, Alice L. ; Singleton, Steven T. ; Olson, James R. ; Rohlman, Diane. / Longitudinal assessment of chlorpyrifos exposure and self-reported neurological symptoms in adolescent pesticide applicators. In: BMJ Open. 2014 ; Vol. 4, No. 3.
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