Longitudinal and cross-sectional analyses of age effects on retinal nerve fiber layer and ganglion cell complex thickness by fourier-domain OCT

Advanced Imaging for Glaucoma Study Group

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose:We studied the effects of age and intraocular pressure (IOP) on retinal nerve fiber layer (NFL) and macular ganglion cell complex (GCC) thickness in normal eyes. Methods:Data from subjects from the multicenter Advanced Imaging for Glaucoma Study (AIGS) were analyzed. The data included yearly visits from the normal subjects in the AIGS study. Fourier-domain optical coherence tomography (FD-OCT) was used to measure retinal NFL and macular GCC on each visit. Mixed effect models were used to evaluate the longitudinal effect of age and IOP on the NFL and GCC thickness. The measurements at baseline were used to examine the cross-sectional effects. Results:The analysis included 192 eyes (92 participants) from AIGS between 2009 and 2013. The longitudinal analyses showed overall GCC thickness decreased 0.25 ± 0.05 μm per year (P< 0.001) while the overall NFL thickness decreased 0.14 ± 0.07 μm per year (P= 0.04). The cross-sectional analyses showed the GCC thickness was 0.17 ± 0.05 μm thinner per year of baseline age (P< 0.001), while the NFL was 0.21 ± 0.06 μm thinner (P< 0.001). There was no significant IOP effect on either GCC or NFL from either the longitudinal or cross-sectional analysis. Conclusions:Longitudinal and cross-sectional analyses provided consistent rates of approximately 0.2% per year of age-related thinning in NFL and GCC thicknesses. This is relevant in establishing criteria to detect glaucoma-related thinning (disease progression) in excess of normal aging. IOP does not seem to be a significant confounder for progression analysis. Translational Relevance:This study demonstrated the relevance of advanced imaging technology in diagnosing and monitoring glaucoma disease.

Original languageEnglish (US)
Article number1
JournalTranslational Vision Science and Technology
Volume5
Issue number2
DOIs
StatePublished - Mar 1 2016

Fingerprint

Nerve Fibers
Ganglia
Cross-Sectional Studies
Glaucoma
Fibers
Intraocular Pressure
Imaging techniques
Pressure effects
Optical tomography
Optical Coherence Tomography
Disease Progression
Aging of materials
Technology
Monitoring

Keywords

  • Ganglion cell complex
  • Nerve fiber layer
  • Optic nerve head
  • Optical coherence tomography (OCT)
  • Thinning

ASJC Scopus subject areas

  • Ophthalmology
  • Biomedical Engineering

Cite this

Longitudinal and cross-sectional analyses of age effects on retinal nerve fiber layer and ganglion cell complex thickness by fourier-domain OCT. / Advanced Imaging for Glaucoma Study Group.

In: Translational Vision Science and Technology, Vol. 5, No. 2, 1, 01.03.2016.

Research output: Contribution to journalArticle

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abstract = "Purpose:We studied the effects of age and intraocular pressure (IOP) on retinal nerve fiber layer (NFL) and macular ganglion cell complex (GCC) thickness in normal eyes. Methods:Data from subjects from the multicenter Advanced Imaging for Glaucoma Study (AIGS) were analyzed. The data included yearly visits from the normal subjects in the AIGS study. Fourier-domain optical coherence tomography (FD-OCT) was used to measure retinal NFL and macular GCC on each visit. Mixed effect models were used to evaluate the longitudinal effect of age and IOP on the NFL and GCC thickness. The measurements at baseline were used to examine the cross-sectional effects. Results:The analysis included 192 eyes (92 participants) from AIGS between 2009 and 2013. The longitudinal analyses showed overall GCC thickness decreased 0.25 ± 0.05 μm per year (P< 0.001) while the overall NFL thickness decreased 0.14 ± 0.07 μm per year (P= 0.04). The cross-sectional analyses showed the GCC thickness was 0.17 ± 0.05 μm thinner per year of baseline age (P< 0.001), while the NFL was 0.21 ± 0.06 μm thinner (P< 0.001). There was no significant IOP effect on either GCC or NFL from either the longitudinal or cross-sectional analysis. Conclusions:Longitudinal and cross-sectional analyses provided consistent rates of approximately 0.2{\%} per year of age-related thinning in NFL and GCC thicknesses. This is relevant in establishing criteria to detect glaucoma-related thinning (disease progression) in excess of normal aging. IOP does not seem to be a significant confounder for progression analysis. Translational Relevance:This study demonstrated the relevance of advanced imaging technology in diagnosing and monitoring glaucoma disease.",
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author = "{Advanced Imaging for Glaucoma Study Group} and Xinbo Zhang and Francis, {Brian A.} and Anna Dastiridou and Vikas Chopra and Ou Tan and Rohit Varma and Greenfield, {David S.} and Schuman, {Joel S.} and David Huang",
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AU - Dastiridou, Anna

AU - Chopra, Vikas

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