Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy

Meera R. Chappidi, Heather J. Chalfin, Daniel J. Johnson, Max Kates, Nikolai A. Sopko, Michael H. Johnson, Jen-Jane Liu, Steven M. Frank, Trinity J. Bivalacqua

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Patients with bladder cancer undergoing radical cystectomy (RC) experience high rates of perioperative blood transfusions (PBTs) and morbidity. The aim of this study was to evaluate the effect of blood storage duration on the risk of adverse perioperative outcomes in this high-risk patient population. Materials and methods In a retrospective review of RC patients from 2010 to 2014 who received PBTs, the average storage duration for all units transfused was used to classify patients as receiving older blood using 3 different definitions (≥21 days,≥28 days, and≥35 days). Multivariable Poisson regression models were used to determine the adjusted relative risk of perioperative infections and overall morbidity in those given older blood compared to fresher blood. Results Of the 451 patients undergoing RC, 205 (45%) received nonirradiated PBTs. In multivariable modeling, increasing average blood storage duration, as a continuous variable, was associated with an increased risk of infections (risk ratio [RR] = 1.08 per day, 95% CI: 1.01–1.17) and overall morbidity (RR = 1.08 per day, 95% CI: 1.01–1.15). Furthermore, ≥28-day blood storage (vs.<28) was associated with increased infections (RR = 2.69, 95% CI: 1.18–6.14) and morbidity (RR = 2.54, 95% CI: 1.31–4.95), and ≥35-day blood storage (vs.<35) was also associated with increased infections (RR = 2.83, 95% CI: 1.42–5.66) and morbidity (RR = 3.35, 95% CI: 1.95–5.77). Conclusions Although blood is stored up to 42 days, storage≥28 days may expose RC patients to increased perioperative infections and overall morbidity compared with storage<28 days. Prospective cohort studies are warranted in cystectomy and other high-risk surgical oncology patients to better determine the effect of blood storage duration.

Original languageEnglish (US)
Pages (from-to)38.e17-38.e24
JournalUrologic Oncology: Seminars and Original Investigations
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2017

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Cystectomy
Morbidity
Infection
Odds Ratio
Blood Transfusion
Urinary Bladder Neoplasms
Cohort Studies
Prospective Studies

Keywords

  • Bladder cancer
  • Blood transfusion
  • Cystectomy
  • Infection
  • Postoperative complications

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy. / Chappidi, Meera R.; Chalfin, Heather J.; Johnson, Daniel J.; Kates, Max; Sopko, Nikolai A.; Johnson, Michael H.; Liu, Jen-Jane; Frank, Steven M.; Bivalacqua, Trinity J.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 35, No. 2, 01.02.2017, p. 38.e17-38.e24.

Research output: Contribution to journalArticle

Chappidi, Meera R. ; Chalfin, Heather J. ; Johnson, Daniel J. ; Kates, Max ; Sopko, Nikolai A. ; Johnson, Michael H. ; Liu, Jen-Jane ; Frank, Steven M. ; Bivalacqua, Trinity J. / Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy. In: Urologic Oncology: Seminars and Original Investigations. 2017 ; Vol. 35, No. 2. pp. 38.e17-38.e24.
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abstract = "Background Patients with bladder cancer undergoing radical cystectomy (RC) experience high rates of perioperative blood transfusions (PBTs) and morbidity. The aim of this study was to evaluate the effect of blood storage duration on the risk of adverse perioperative outcomes in this high-risk patient population. Materials and methods In a retrospective review of RC patients from 2010 to 2014 who received PBTs, the average storage duration for all units transfused was used to classify patients as receiving older blood using 3 different definitions (≥21 days,≥28 days, and≥35 days). Multivariable Poisson regression models were used to determine the adjusted relative risk of perioperative infections and overall morbidity in those given older blood compared to fresher blood. Results Of the 451 patients undergoing RC, 205 (45{\%}) received nonirradiated PBTs. In multivariable modeling, increasing average blood storage duration, as a continuous variable, was associated with an increased risk of infections (risk ratio [RR] = 1.08 per day, 95{\%} CI: 1.01–1.17) and overall morbidity (RR = 1.08 per day, 95{\%} CI: 1.01–1.15). Furthermore, ≥28-day blood storage (vs.<28) was associated with increased infections (RR = 2.69, 95{\%} CI: 1.18–6.14) and morbidity (RR = 2.54, 95{\%} CI: 1.31–4.95), and ≥35-day blood storage (vs.<35) was also associated with increased infections (RR = 2.83, 95{\%} CI: 1.42–5.66) and morbidity (RR = 3.35, 95{\%} CI: 1.95–5.77). Conclusions Although blood is stored up to 42 days, storage≥28 days may expose RC patients to increased perioperative infections and overall morbidity compared with storage<28 days. Prospective cohort studies are warranted in cystectomy and other high-risk surgical oncology patients to better determine the effect of blood storage duration.",
keywords = "Bladder cancer, Blood transfusion, Cystectomy, Infection, Postoperative complications",
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T1 - Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy

AU - Chappidi, Meera R.

AU - Chalfin, Heather J.

AU - Johnson, Daniel J.

AU - Kates, Max

AU - Sopko, Nikolai A.

AU - Johnson, Michael H.

AU - Liu, Jen-Jane

AU - Frank, Steven M.

AU - Bivalacqua, Trinity J.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Background Patients with bladder cancer undergoing radical cystectomy (RC) experience high rates of perioperative blood transfusions (PBTs) and morbidity. The aim of this study was to evaluate the effect of blood storage duration on the risk of adverse perioperative outcomes in this high-risk patient population. Materials and methods In a retrospective review of RC patients from 2010 to 2014 who received PBTs, the average storage duration for all units transfused was used to classify patients as receiving older blood using 3 different definitions (≥21 days,≥28 days, and≥35 days). Multivariable Poisson regression models were used to determine the adjusted relative risk of perioperative infections and overall morbidity in those given older blood compared to fresher blood. Results Of the 451 patients undergoing RC, 205 (45%) received nonirradiated PBTs. In multivariable modeling, increasing average blood storage duration, as a continuous variable, was associated with an increased risk of infections (risk ratio [RR] = 1.08 per day, 95% CI: 1.01–1.17) and overall morbidity (RR = 1.08 per day, 95% CI: 1.01–1.15). Furthermore, ≥28-day blood storage (vs.<28) was associated with increased infections (RR = 2.69, 95% CI: 1.18–6.14) and morbidity (RR = 2.54, 95% CI: 1.31–4.95), and ≥35-day blood storage (vs.<35) was also associated with increased infections (RR = 2.83, 95% CI: 1.42–5.66) and morbidity (RR = 3.35, 95% CI: 1.95–5.77). Conclusions Although blood is stored up to 42 days, storage≥28 days may expose RC patients to increased perioperative infections and overall morbidity compared with storage<28 days. Prospective cohort studies are warranted in cystectomy and other high-risk surgical oncology patients to better determine the effect of blood storage duration.

AB - Background Patients with bladder cancer undergoing radical cystectomy (RC) experience high rates of perioperative blood transfusions (PBTs) and morbidity. The aim of this study was to evaluate the effect of blood storage duration on the risk of adverse perioperative outcomes in this high-risk patient population. Materials and methods In a retrospective review of RC patients from 2010 to 2014 who received PBTs, the average storage duration for all units transfused was used to classify patients as receiving older blood using 3 different definitions (≥21 days,≥28 days, and≥35 days). Multivariable Poisson regression models were used to determine the adjusted relative risk of perioperative infections and overall morbidity in those given older blood compared to fresher blood. Results Of the 451 patients undergoing RC, 205 (45%) received nonirradiated PBTs. In multivariable modeling, increasing average blood storage duration, as a continuous variable, was associated with an increased risk of infections (risk ratio [RR] = 1.08 per day, 95% CI: 1.01–1.17) and overall morbidity (RR = 1.08 per day, 95% CI: 1.01–1.15). Furthermore, ≥28-day blood storage (vs.<28) was associated with increased infections (RR = 2.69, 95% CI: 1.18–6.14) and morbidity (RR = 2.54, 95% CI: 1.31–4.95), and ≥35-day blood storage (vs.<35) was also associated with increased infections (RR = 2.83, 95% CI: 1.42–5.66) and morbidity (RR = 3.35, 95% CI: 1.95–5.77). Conclusions Although blood is stored up to 42 days, storage≥28 days may expose RC patients to increased perioperative infections and overall morbidity compared with storage<28 days. Prospective cohort studies are warranted in cystectomy and other high-risk surgical oncology patients to better determine the effect of blood storage duration.

KW - Bladder cancer

KW - Blood transfusion

KW - Cystectomy

KW - Infection

KW - Postoperative complications

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