Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy

Giovanni Schifitto; C. Yiannoutsos; D. M. Simpson; B. T. Adornato; E. J. Singer; H. Hollander; C. M. Marra; M. Rubin; B. A. Cohen; T. Tucker; I. J. Koralnik; D. Katzenstein; B. Haidich; M. E. Smith; S. Shriver; L. Millar; D. B. Clifford; J. C. McArthur

doi:10.1212/WNL.57.7.1313

Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy

Giovanni Schifitto, C. Yiannoutsos, D. M. Simpson, B. T. Adornato, E. J. Singer, H. Hollander, C. M. Marra, M. Rubin, B. A. Cohen, T. Tucker, I. J. Koralnik, D. Katzenstein, B. Haidich, M. E. Smith, S. Shriver, L. Millar, D. B. Clifford, J. C. McArthur

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.

Original language	English (US)
Pages (from-to)	1313-1316
Number of pages	4
Journal	Neurology
Volume	57
Issue number	7
DOIs	https://doi.org/10.1212/WNL.57.7.1313
State	Published - Oct 9 2001
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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Schifitto, G., Yiannoutsos, C., Simpson, D. M., Adornato, B. T., Singer, E. J., Hollander, H., Marra, C. M., Rubin, M., Cohen, B. A., Tucker, T., Koralnik, I. J., Katzenstein, D., Haidich, B., Smith, M. E., Shriver, S., Millar, L., Clifford, D. B., & McArthur, J. C. (2001). Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy. Neurology, 57(7), 1313-1316. https://doi.org/10.1212/WNL.57.7.1313

Schifitto, G, Yiannoutsos, C, Simpson, DM, Adornato, BT, Singer, EJ, Hollander, H, Marra, CM, Rubin, M, Cohen, BA, Tucker, T, Koralnik, IJ, Katzenstein, D, Haidich, B, Smith, ME, Shriver, S, Millar, L, Clifford, DB & McArthur, JC 2001, 'Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy', Neurology, vol. 57, no. 7, pp. 1313-1316. https://doi.org/10.1212/WNL.57.7.1313

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abstract = "HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.",

author = "Giovanni Schifitto and C. Yiannoutsos and Simpson, {D. M.} and Adornato, {B. T.} and Singer, {E. J.} and H. Hollander and Marra, {C. M.} and M. Rubin and Cohen, {B. A.} and T. Tucker and Koralnik, {I. J.} and D. Katzenstein and B. Haidich and Smith, {M. E.} and S. Shriver and L. Millar and Clifford, {D. B.} and McArthur, {J. C.}",

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AU - Simpson, D. M.

AU - Adornato, B. T.

AU - Singer, E. J.

AU - Hollander, H.

AU - Marra, C. M.

AU - Rubin, M.

AU - Cohen, B. A.

AU - Tucker, T.

AU - Koralnik, I. J.

AU - Katzenstein, D.

AU - Haidich, B.

AU - Smith, M. E.

AU - Shriver, S.

AU - Millar, L.

AU - Clifford, D. B.

AU - McArthur, J. C.

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AB - HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.

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Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy

Abstract

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