Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum

Joan E. Rubinstein; Robert J. Hitzemann; Charles R. Ashby; Rex Y. Wang

doi:10.1016/0006-8993(89)91094-9

Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D₂ dopaminergic agonists in rat striatum

Joan E. Rubinstein, Robert J. Hitzemann, Charles R. Ashby, Rex Y. Wang

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The effects of the muscarinic agonist carbachol and the D₂ dopaminergic agonist quinpirole on phosphoinositide hydrolysis were studied in the corpus striatum of rats which had been treated for one year with either haloperidol or clozapine. In the presence of LiCl, carbachol increased the accumulation of inositol monophosphate (/s>100%) and bisposphate (/s>20%). Quinpirole had no effect on either basal or carbachol-stimulated accumulation of inositol phosphates. There was no difference in these responses between the drug-treated animals and age-matched controls.

Original language	English (US)
Pages (from-to)	385-388
Number of pages	4
Journal	Brain research
Volume	496
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(89)91094-9
State	Published - Sep 4 1989
Externally published	Yes

Keywords

Antipsychotic drug
Chronic drug treatment
Clozapine
D dopamine receptor
Haloperidol
Inositol phosphate
Muscarinic receptor
Rat striatum

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(89)91094-9

Cite this

@article{0b79d40b5ebe48af82d274f5308e4b35,

title = "Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum",

abstract = "The effects of the muscarinic agonist carbachol and the D2 dopaminergic agonist quinpirole on phosphoinositide hydrolysis were studied in the corpus striatum of rats which had been treated for one year with either haloperidol or clozapine. In the presence of LiCl, carbachol increased the accumulation of inositol monophosphate (/s>100%) and bisposphate (/s>20%). Quinpirole had no effect on either basal or carbachol-stimulated accumulation of inositol phosphates. There was no difference in these responses between the drug-treated animals and age-matched controls.",

keywords = "Antipsychotic drug, Chronic drug treatment, Clozapine, D dopamine receptor, Haloperidol, Inositol phosphate, Muscarinic receptor, Rat striatum",

author = "Rubinstein, {Joan E.} and Hitzemann, {Robert J.} and Ashby, {Charles R.} and Wang, {Rex Y.}",

note = "Funding Information: This work was supported by USPHS Grants Kll MH-00747 (to J.E.R.), MH-41440 and MH-00378 (to R.Y.W.), and MH-43385 and V.A. Res. Serv. (to R.J.H.). We thank Deyuan Jiang for her technical assistancew ith animal care and gratefully acknowledge the donations of haloperidol, clozapine and quinpirole from McNeil, Sandoz and Eli Lilly, respectively.",

year = "1989",

month = sep,

day = "4",

doi = "10.1016/0006-8993(89)91094-9",

language = "English (US)",

volume = "496",

pages = "385--388",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

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T1 - Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum

AU - Rubinstein, Joan E.

AU - Hitzemann, Robert J.

AU - Ashby, Charles R.

AU - Wang, Rex Y.

N1 - Funding Information: This work was supported by USPHS Grants Kll MH-00747 (to J.E.R.), MH-41440 and MH-00378 (to R.Y.W.), and MH-43385 and V.A. Res. Serv. (to R.J.H.). We thank Deyuan Jiang for her technical assistancew ith animal care and gratefully acknowledge the donations of haloperidol, clozapine and quinpirole from McNeil, Sandoz and Eli Lilly, respectively.

PY - 1989/9/4

Y1 - 1989/9/4

N2 - The effects of the muscarinic agonist carbachol and the D2 dopaminergic agonist quinpirole on phosphoinositide hydrolysis were studied in the corpus striatum of rats which had been treated for one year with either haloperidol or clozapine. In the presence of LiCl, carbachol increased the accumulation of inositol monophosphate (/s>100%) and bisposphate (/s>20%). Quinpirole had no effect on either basal or carbachol-stimulated accumulation of inositol phosphates. There was no difference in these responses between the drug-treated animals and age-matched controls.

AB - The effects of the muscarinic agonist carbachol and the D2 dopaminergic agonist quinpirole on phosphoinositide hydrolysis were studied in the corpus striatum of rats which had been treated for one year with either haloperidol or clozapine. In the presence of LiCl, carbachol increased the accumulation of inositol monophosphate (/s>100%) and bisposphate (/s>20%). Quinpirole had no effect on either basal or carbachol-stimulated accumulation of inositol phosphates. There was no difference in these responses between the drug-treated animals and age-matched controls.

KW - Antipsychotic drug

KW - Chronic drug treatment

KW - Clozapine

KW - D dopamine receptor

KW - Haloperidol

KW - Inositol phosphate

KW - Muscarinic receptor

KW - Rat striatum

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DO - 10.1016/0006-8993(89)91094-9

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