Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum

Joan E. Rubinstein, Robert Hitzemann, Charles R. Ashby, Rex Y. Wang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of the muscarinic agonist carbachol and the D2 dopaminergic agonist quinpirole on phosphoinositide hydrolysis were studied in the corpus striatum of rats which had been treated for one year with either haloperidol or clozapine. In the presence of LiCl, carbachol increased the accumulation of inositol monophosphate (/s>100%) and bisposphate (/s>20%). Quinpirole had no effect on either basal or carbachol-stimulated accumulation of inositol phosphates. There was no difference in these responses between the drug-treated animals and age-matched controls.

Original languageEnglish (US)
Pages (from-to)385-388
Number of pages4
JournalBrain Research
Volume496
Issue number1-2
DOIs
StatePublished - Sep 4 1989
Externally publishedYes

Fingerprint

Dopamine Agonists
Carbachol
Phosphatidylinositols
Cholinergic Agents
Antipsychotic Agents
Quinpirole
Corpus Striatum
Muscarinic Agonists
Inositol Phosphates
Clozapine
Haloperidol
Inositol
Hydrolysis
Pharmaceutical Preparations

Keywords

  • Antipsychotic drug
  • Chronic drug treatment
  • Clozapine
  • D dopamine receptor
  • Haloperidol
  • Inositol phosphate
  • Muscarinic receptor
  • Rat striatum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum. / Rubinstein, Joan E.; Hitzemann, Robert; Ashby, Charles R.; Wang, Rex Y.

In: Brain Research, Vol. 496, No. 1-2, 04.09.1989, p. 385-388.

Research output: Contribution to journalArticle

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