Long-term treatment with antipsychotics does not alter the phosphoinositide response to muscarinic or D2 dopaminergic agonists in rat striatum

Joan E. Rubinstein, Robert J. Hitzemann, Charles R. Ashby, Rex Y. Wang

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effects of the muscarinic agonist carbachol and the D2 dopaminergic agonist quinpirole on phosphoinositide hydrolysis were studied in the corpus striatum of rats which had been treated for one year with either haloperidol or clozapine. In the presence of LiCl, carbachol increased the accumulation of inositol monophosphate (/s>100%) and bisposphate (/s>20%). Quinpirole had no effect on either basal or carbachol-stimulated accumulation of inositol phosphates. There was no difference in these responses between the drug-treated animals and age-matched controls.

Original languageEnglish (US)
Pages (from-to)385-388
Number of pages4
JournalBrain research
Volume496
Issue number1-2
DOIs
StatePublished - Sep 4 1989

Keywords

  • Antipsychotic drug
  • Chronic drug treatment
  • Clozapine
  • D dopamine receptor
  • Haloperidol
  • Inositol phosphate
  • Muscarinic receptor
  • Rat striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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